Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis

• Published in: PloS one Vol. 8; no. 7; p. e68451
• Main Authors: Salomon, Carlos, Ryan, Jennifer, Sobrevia, Luis, Kobayashi, Miharu, Ashman, Keith, Mitchell, Murray, Rice, Gregory E
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.07.2013; Public Library of Science (PLoS)
• Subjects: Angiogenesis; Biology; Bone marrow; Cancer; CD63 antigen; CD81 antigen; CD9 antigen; Cell adhesion & migration; Cell Hypoxia - drug effects; Cell interactions; Cell migration; Cell Movement - drug effects; Centrifugation; Conditioning; Cytoskeleton; Electron microscopy; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelium; Exosomes; Exosomes - drug effects; Exosomes - metabolism; Female; Fetuses; Gestation; Humans; Hypoxia; Immunomodulation; Kinases; Kinetics; Laboratories; Mass Spectrometry; Mass spectroscopy; Media (differential); Medicine; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - metabolism; Mesenchyme; Metastasis; Microvasculature; Microvessels - cytology; Neovascularization, Physiologic - drug effects; Oxygen; Oxygen - pharmacology; Oxygen tension; Paracrine signalling; Physiology; Placenta; Placenta - cytology; Pregnancy; Proteins; Proteomics; Signal Transduction - drug effects; Software; Stem cells; Tension; Transplants & implants; Queensland Australia

Vasculogenesis and angiogenesis are critical processes in fetal circulation and placental vasculature development. Placental mesenchymal stem cells (pMSC) are known to release paracrine factors (some of which are contained within exosomes) that promote angiogenesis and cell migration. The aims of th...