A method for WD40 repeat detection and secondary structure prediction

• Published in: PloS one Vol. 8; no. 6; p. e65705
• Main Authors: Wang, Yang, Jiang, Fan, Zhuo, Zhu, Wu, Xian-Hui, Wu, Yun-Dong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.06.2013; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Biology; Computational chemistry; Databases, Protein; Deoxyribonucleic acid; DNA; Eukaryotes; Gene sequencing; Genomics; Humans; Hydrogen; Kinases; Laboratories; LRRK2 protein; Membrane Proteins; Methods; Neoplasm Proteins; Nucleotide sequence; Parkinson's disease; Protein families; Protein folding; Protein structure; Protein Structure, Secondary; Proteins; Proteins - chemistry; Ribonucleic acid; RNA; Secondary structure; Trends

WD40-repeat proteins (WD40s), as one of the largest protein families in eukaryotes, play vital roles in assembling protein-protein/DNA/RNA complexes. WD40s fold into similar β-propeller structures despite diversified sequences. A program WDSP (WD40 repeat protein Structure Predictor) has been develo...