Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis

• Published in: PloS one Vol. 12; no. 9; p. e0185406
• Main Authors: Chen, Lei, Yang, Wenjin, Guo, Yijun, Chen, Wei, Zheng, Ping, Zeng, Jinsong, Tong, Wusong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.09.2017; Public Library of Science (PLoS)
• Subjects: Analysis; Animal models; Animals; Antisense RNA; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Arteriosclerosis; Atherogenesis; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; Atherosclerosis - pathology; Biology and life sciences; Cancer; Cell growth; Cell Line; Cytokines; Deoxyribonucleic acid; Development and progression; DNA; Endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - pathology; Exosomes; Exosomes - genetics; Gene expression; Gene Knockdown Techniques; Genetic aspects; Hospitals; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins; Lipoproteins, LDL - pharmacology; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Macrophages - pathology; Medicine and Health Sciences; Neurosurgery; Physiological aspects; Research and Analysis Methods; Ribonucleic acid; RNA; RNA, Long Noncoding - antagonists & inhibitors; RNA, Long Noncoding - genetics; RNA, Small Nucleolar - genetics; Stimulation; Studies; Thrombosis; Up-Regulation; Veins & arteries; China

Atherosclerosis is universally recognized as a chronic lipid-induced inflammation of the vessel wall. Oxidized low density lipoprotein (oxLDL) drives the onset of atherogenesis involving macrophages and endothelial cells (ECs). Our earlier work showed that expression of long noncoding RNA-growth arr...