Different Effects of Three Selected Lactobacillus Strains in Dextran Sulfate Sodium-Induced Colitis in BALB/c Mice

• Published in: PloS one Vol. 11; no. 2; p. e0148241
• Main Authors: Cui, Yi, Wei, Hongyun, Lu, Fanggen, Liu, Xiaowei, Liu, Deliang, Gu, Li, Ouyang, Chunhui
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.02.2016; Public Library of Science (PLoS)
• Subjects: Active control; Adult; Animals; Antibiotics; Biology and Life Sciences; Biotherapy; Body weight; Body weight loss; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - therapy; Colon; Colon - microbiology; Colon - pathology; Damage detection; Deoxyribonucleic acid; Dextran; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; DNA; Feces; Feces - microbiology; Female; Gastroenterology; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - genetics; Health aspects; Hospitals; Humans; Immunology; Infiltration; Inflammatory bowel disease; Inflammatory bowel diseases; Lactobacillus; Lactobacillus - classification; Lactobacillus plantarum; Male; Medicine and Health Sciences; Methods; Mice; Mice, Inbred BALB C; Patients; Polymerase chain reaction; Population decline; Prebiotics; Probiotics; Probiotics - therapeutic use; Qualitative analysis; Quantitative analysis; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Rodents; Severity of Illness Index; Sodium; Species; Sulfates; Ulcerative colitis; Weight loss; Weight Loss - drug effects; United States > US

To analyze the changes of different Lactobacillus species in ulcerative colitis patients and to further assess the therapeutic effects of selected Lactobacillus strains on dextran sulfate sodium (DSS)-induced experimental colitis in BALB/c mice. Forty-five active ulcerative colitis (UC) patients and...