Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese

• Published in: PloS one Vol. 8; no. 6; p. e66920
• Main Authors: Wong, Danny Ka-Ho, Watanabe, Tsunamasa, Tanaka, Yasuhito, Seto, Wai-Kay, Lee, Cheuk-Kwong, Fung, James, Lin, Che-Kit, Huang, Fung-Yu, Lai, Ching-Lung, Yuen, Man-Fung
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.06.2013; Public Library of Science (PLoS)
• Subjects: Alanine; Alanine transaminase; Alleles; Analysis; Antigen presentation; Asian Continental Ancestry Group - genetics; Biology; Blood & organ donations; Blood transfusions; Carriers; Chromosomes; Chronic infection; Core protein; Deoxyribonucleic acid; DNA; Female; Genetic aspects; Genomes; Genotypes; Haplotypes; Health aspects; Hepatitis; Hepatitis B; Hepatitis B surface antigen; Hepatitis B, Chronic - genetics; Hepatology; Histocompatibility antigen HLA; Histocompatibility antigens; HLA histocompatibility antigens; HLA-DP Antigens - genetics; Hong Kong - epidemiology; Hospitals; Humans; Infection; Infections; Interferon; Laboratories; Liver cancer; Male; Medical research; Medicine; Medicine, Experimental; Middle Aged; Minority & ethnic groups; Polymorphism, Single Nucleotide; Population studies; Populations; Prevalence; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Tat protein; Virology; Viruses; Hong Kong; Hong Kong China; China

The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. We genotyped...