Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese

The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. We genotyped...

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Published inPloS one Vol. 8; no. 6; p. e66920
Main Authors Wong, Danny Ka-Ho, Watanabe, Tsunamasa, Tanaka, Yasuhito, Seto, Wai-Kay, Lee, Cheuk-Kwong, Fung, James, Lin, Che-Kit, Huang, Fung-Yu, Lai, Ching-Lung, Yuen, Man-Fung
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 25.06.2013
Public Library of Science (PLoS)
Subjects
Alanine
Alanine transaminase
Alleles
Analysis
Antigen presentation
Asian Continental Ancestry Group - genetics
Biology
Blood & organ donations
Blood transfusions
Carriers
Chromosomes
Chronic infection
Core protein
Deoxyribonucleic acid
DNA
Female
Genetic aspects
Genomes
Genotypes
Haplotypes
Health aspects
Hepatitis
Hepatitis B
Hepatitis B surface antigen
Hepatitis B, Chronic - genetics
Hepatology
Histocompatibility antigen HLA
Histocompatibility antigens
HLA histocompatibility antigens
HLA-DP Antigens - genetics
Hong Kong - epidemiology
Hospitals
Humans
Infection
Infections
Interferon
Laboratories
Liver cancer
Male
Medical research
Medicine
Medicine, Experimental
Middle Aged
Minority & ethnic groups
Polymorphism, Single Nucleotide
Population studies
Populations
Prevalence
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Tat protein
Virology
Viruses
Hong Kong
Hong Kong China
China
Online AccessGet full text

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Abstract The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months. Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity. HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
AbstractList The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months. Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity. HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
Background and Aims The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. Methods We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months. Results Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity. Conclusion HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months. Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity. HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong.BACKGROUND AND AIMSThe association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong.We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months.METHODSWe genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months.Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity.RESULTSCompared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity.HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.CONCLUSIONHLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
Background and Aims The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. Methods We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months. Results Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity. Conclusion HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
Background and aimsThe association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong.MethodsWe genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels <2,000 IU/ml and persistently normal alanine aminotransferase level for least 12 months.ResultsCompared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (p = 0.0040), rs9277378 A allele (p = 0.0068) and a trend for lower frequency of rs3128917 T allele (p = 0.054). These alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, p = 0.0083; rs9277378: OR = 1.61, p = 0.00011; rs3128917: OR = 1.54, p = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, p = 0.0013). No association was found between these SNPs and HBV disease activity.ConclusionHLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
Audience Academic
Author Seto, Wai-Kay
Fung, James
Watanabe, Tsunamasa
Lai, Ching-Lung
Lin, Che-Kit
Lee, Cheuk-Kwong
Huang, Fung-Yu
Yuen, Man-Fung
Wong, Danny Ka-Ho
Tanaka, Yasuhito
AuthorAffiliation 1 Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
4 Hong Kong Red Cross Blood Transfusion Service, Hospital Authority, Hong Kong
University of Modena & Reggio Emilia, Italy
2 State Key Laboratory for Liver Research, The University of Hong Kong, Queen Mary Hospital, Hong Kong
3 Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
AuthorAffiliation_xml – name: 2 State Key Laboratory for Liver Research, The University of Hong Kong, Queen Mary Hospital, Hong Kong
– name: University of Modena & Reggio Emilia, Italy
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– name: 4 Hong Kong Red Cross Blood Transfusion Service, Hospital Authority, Hong Kong
– name: 3 Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/23825586$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1371/journal.pone.0017608
10.1002/hep.20716
10.1128/JVI.00867-09
10.1371/journal.pone.0028798
10.1093/intimm/dxg057
10.1093/infdis/jiq154
10.1016/S0166-3542(01)00175-9
10.1038/nature09298
10.1371/journal.pgen.1002791
10.1002/hep.20318
10.1086/314614
10.1053/jhep.2000.7988
10.1086/519795
10.1002/hep.24799
10.1111/j.1572-0241.2003.07179.x
10.1002/hep.24048
10.1002/hep.20614
10.1371/journal.pone.0032605
10.1128/JVI.78.20.11258-11262.2004
10.1371/journal.pone.0039175
10.1016/S0140-6736(96)05409-8
10.1093/hmg/ddr301
10.1371/journal.pone.0024221
10.1073/pnas.220430797
10.1056/NEJM199504203321604
10.1038/gene.2011.11
10.1038/ng.348
ContentType Journal Article
Copyright COPYRIGHT 2013 Public Library of Science
2013 Wong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2013 Wong et al 2013 Wong et al
Copyright_xml – notice: COPYRIGHT 2013 Public Library of Science
– notice: 2013 Wong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2013 Wong et al 2013 Wong et al
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Critical revision of manuscript: YT CLL MFY
Study supervision: MFY.
Competing Interests: Man-Fung Yuen and James Fung are PLOS ONE Editorial Board members. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: DKHW TW YT MFY. Performed the experiments: DKHW TW. Analyzed the data: DKHW TW WKS JF. Contributed reagents/materials/analysis tools: DKHW TW FYH. Wrote the paper: DKHW. Recruitment of study subjects: WKS CKL JF CKL
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References J Li (ref20) 2011; 6
AP Fontenot (ref26) 2000; 97
G Diaz (ref27) 2003; 15
M Thursz (ref3) 2001; 52
A Godkin (ref9) 2005; 41
TM Lin (ref2) 1989; 9
G Deng (ref5) 2004; 40
L Hu (ref17) 2012; 55
MR Thursz (ref10) 1995; 332
P An (ref21) 2011; 203
CL Lai (ref1) 2003; 362
HC Thomas (ref7) 1996; 348
Z Ben-Ari (ref4) 2003; 98
C International HapMap (ref22) 2010; 467
CL Thio (ref8) 2004; 78
SH Ahn (ref12) 2000; 31
N Nishida (ref15) 2012; 7
S Li (ref30) 2012; 8
R Bellamy (ref6) 1999; 179
X Guo (ref16) 2011; 53
H Mbarek (ref14) 2011; 20
A Penna (ref24) 1997; 25
S Urbani (ref25) 2005; 41
S Asabe (ref29) 2009; 83
L Wang (ref19) 2011; 6
TR O’Brien (ref28) 2011; 12
T Hohler (ref11) 1997; 26
S Purcell (ref23) 2007; 81
KY Chan (ref31) 2011; 6
Y Kamatani (ref13) 2009; 41
J Vermehren (ref18) 2012; 7
21408128 - PLoS One. 2011;6(3):e17608
21750111 - Hum Mol Genet. 2011 Oct 1;20(19):3884-92
15915462 - Hepatology. 2005 Jun;41(6):1383-90
9075656 - J Hepatol. 1997 Mar;26(3):503-7
8965590 - Lancet. 1996 Nov 23;348(9039):1417-9
21346778 - Genes Immun. 2011 Sep;12(6):428-33
10827165 - Hepatology. 2000 Jun;31(6):1371-3
17701901 - Am J Hum Genet. 2007 Sep;81(3):559-75
22105689 - Hepatology. 2012 May;55(5):1426-31
12697658 - Int Immunol. 2003 May;15(5):565-76
14697813 - Lancet. 2003 Dec 20;362(9401):2089-94
20811451 - Nature. 2010 Sep 2;467(7311):52-8
15368436 - Hepatology. 2004 Aug;40(2):318-26
21274863 - Hepatology. 2011 Feb;53(2):422-8
21904616 - PLoS One. 2011;6(8):e24221
22448225 - PLoS One. 2012;7(3):e32605
11672820 - Antiviral Res. 2001 Nov;52(2):113-6
15452244 - J Virol. 2004 Oct;78(20):11258-62
9096614 - Hepatology. 1997 Apr;25(4):1022-7
9952386 - J Infect Dis. 1999 Mar;179(3):721-4
2764519 - Anticancer Res. 1989 May-Jun;9(3):737-41
19625407 - J Virol. 2009 Oct;83(19):9652-62
15726541 - Hepatology. 2005 Apr;41(4):826-31
22807686 - PLoS Genet. 2012;8(7):e1002791
11050177 - Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12717-22
22737229 - PLoS One. 2012;7(6):e39175
21402545 - J Infect Dis. 2011 Apr 1;203(7):943-7
19349983 - Nat Genet. 2009 May;41(5):591-5
22174901 - PLoS One. 2011;6(12):e28798
7898524 - N Engl J Med. 1995 Apr 20;332(16):1065-9
12526950 - Am J Gastroenterol. 2003 Jan;98(1):144-50
References_xml – volume: 6
  start-page: e17608
  year: 2011
  ident: ref19
  article-title: Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0017608
– volume: 41
  start-page: 1383
  year: 2005
  ident: ref9
  article-title: Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness
  publication-title: Hepatology
  doi: 10.1002/hep.20716
– volume: 83
  start-page: 9652
  year: 2009
  ident: ref29
  article-title: The size of the viral inoculum contributes to the outcome of hepatitis B virus infection
  publication-title: J Virol
  doi: 10.1128/JVI.00867-09
– volume: 6
  start-page: e28798
  year: 2011
  ident: ref31
  article-title: Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0028798
– volume: 9
  start-page: 737
  year: 1989
  ident: ref2
  article-title: Hepatitis B virus markers in Chinese twins
  publication-title: Anticancer Res
– volume: 15
  start-page: 565
  year: 2003
  ident: ref27
  article-title: Functional analysis of HLA-DP polymorphism: a crucial role for DPbeta residues 9, 11, 35, 55, 56, 69 and 84–87 in T cell allorecognition and peptide binding
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxg057
– volume: 203
  start-page: 943
  year: 2011
  ident: ref21
  article-title: A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiq154
– volume: 52
  start-page: 113
  year: 2001
  ident: ref3
  article-title: Genetic susceptibility in chronic viral hepatitis
  publication-title: Antiviral Res
  doi: 10.1016/S0166-3542(01)00175-9
– volume: 467
  start-page: 52
  year: 2010
  ident: ref22
  article-title: Integrating common and rare genetic variation in diverse human populations
  publication-title: Nature
  doi: 10.1038/nature09298
– volume: 8
  start-page: e1002791
  year: 2012
  ident: ref30
  article-title: GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1002791
– volume: 40
  start-page: 318
  year: 2004
  ident: ref5
  article-title: Association of estrogen receptor alpha polymorphisms with susceptibility to chronic hepatitis B virus infection
  publication-title: Hepatology
  doi: 10.1002/hep.20318
– volume: 179
  start-page: 721
  year: 1999
  ident: ref6
  article-title: Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene
  publication-title: J Infect Dis
  doi: 10.1086/314614
– volume: 25
  start-page: 1022
  year: 1997
  ident: ref24
  article-title: Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology
– volume: 31
  start-page: 1371
  year: 2000
  ident: ref12
  article-title: Association between hepatitis B virus infection and HLA-DR type in Korea
  publication-title: Hepatology
  doi: 10.1053/jhep.2000.7988
– volume: 81
  start-page: 559
  year: 2007
  ident: ref23
  article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses
  publication-title: Am J Hum Genet
  doi: 10.1086/519795
– volume: 55
  start-page: 1426
  year: 2012
  ident: ref17
  article-title: Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development
  publication-title: Hepatology
  doi: 10.1002/hep.24799
– volume: 98
  start-page: 144
  year: 2003
  ident: ref4
  article-title: Cytokine gene polymorphisms in patients infected with hepatitis B virus
  publication-title: Am J Gastroenterol
  doi: 10.1111/j.1572-0241.2003.07179.x
– volume: 362
  start-page: 2089
  year: 2003
  ident: ref1
  article-title: Viral hepatitis B. Lancet
– volume: 53
  start-page: 422
  year: 2011
  ident: ref16
  article-title: Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population
  publication-title: Hepatology
  doi: 10.1002/hep.24048
– volume: 41
  start-page: 826
  year: 2005
  ident: ref25
  article-title: Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection
  publication-title: Hepatology
  doi: 10.1002/hep.20614
– volume: 7
  start-page: e32605
  year: 2012
  ident: ref18
  article-title: A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0032605
– volume: 26
  start-page: 503
  year: 1997
  ident: ref11
  article-title: HLA-DRB1*1301 and *1302 protect against chronic hepatitis B. J Hepatol
– volume: 78
  start-page: 11258
  year: 2004
  ident: ref8
  article-title: Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection
  publication-title: J Virol
  doi: 10.1128/JVI.78.20.11258-11262.2004
– volume: 7
  start-page: e39175
  year: 2012
  ident: ref15
  article-title: Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0039175
– volume: 348
  start-page: 1417
  year: 1996
  ident: ref7
  article-title: Mutation of gene of mannose-binding protein associated with chronic hepatitis B viral infection
  publication-title: Lancet
  doi: 10.1016/S0140-6736(96)05409-8
– volume: 20
  start-page: 3884
  year: 2011
  ident: ref14
  article-title: A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddr301
– volume: 6
  start-page: e24221
  year: 2011
  ident: ref20
  article-title: Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0024221
– volume: 97
  start-page: 12717
  year: 2000
  ident: ref26
  article-title: Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.220430797
– volume: 332
  start-page: 1065
  year: 1995
  ident: ref10
  article-title: Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199504203321604
– volume: 12
  start-page: 428
  year: 2011
  ident: ref28
  article-title: Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver
  publication-title: Genes Immun
  doi: 10.1038/gene.2011.11
– volume: 41
  start-page: 591
  year: 2009
  ident: ref13
  article-title: A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
  publication-title: Nat Genet
  doi: 10.1038/ng.348
– reference: 15452244 - J Virol. 2004 Oct;78(20):11258-62
– reference: 21346778 - Genes Immun. 2011 Sep;12(6):428-33
– reference: 11050177 - Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12717-22
– reference: 21904616 - PLoS One. 2011;6(8):e24221
– reference: 19349983 - Nat Genet. 2009 May;41(5):591-5
– reference: 22737229 - PLoS One. 2012;7(6):e39175
– reference: 20811451 - Nature. 2010 Sep 2;467(7311):52-8
– reference: 12526950 - Am J Gastroenterol. 2003 Jan;98(1):144-50
– reference: 21402545 - J Infect Dis. 2011 Apr 1;203(7):943-7
– reference: 2764519 - Anticancer Res. 1989 May-Jun;9(3):737-41
– reference: 14697813 - Lancet. 2003 Dec 20;362(9401):2089-94
– reference: 21750111 - Hum Mol Genet. 2011 Oct 1;20(19):3884-92
– reference: 19625407 - J Virol. 2009 Oct;83(19):9652-62
– reference: 9075656 - J Hepatol. 1997 Mar;26(3):503-7
– reference: 22174901 - PLoS One. 2011;6(12):e28798
– reference: 9952386 - J Infect Dis. 1999 Mar;179(3):721-4
– reference: 21274863 - Hepatology. 2011 Feb;53(2):422-8
– reference: 22105689 - Hepatology. 2012 May;55(5):1426-31
– reference: 11672820 - Antiviral Res. 2001 Nov;52(2):113-6
– reference: 21408128 - PLoS One. 2011;6(3):e17608
– reference: 12697658 - Int Immunol. 2003 May;15(5):565-76
– reference: 7898524 - N Engl J Med. 1995 Apr 20;332(16):1065-9
– reference: 15726541 - Hepatology. 2005 Apr;41(4):826-31
– reference: 22448225 - PLoS One. 2012;7(3):e32605
– reference: 9096614 - Hepatology. 1997 Apr;25(4):1022-7
– reference: 10827165 - Hepatology. 2000 Jun;31(6):1371-3
– reference: 17701901 - Am J Hum Genet. 2007 Sep;81(3):559-75
– reference: 15368436 - Hepatology. 2004 Aug;40(2):318-26
– reference: 15915462 - Hepatology. 2005 Jun;41(6):1383-90
– reference: 22807686 - PLoS Genet. 2012;8(7):e1002791
– reference: 8965590 - Lancet. 1996 Nov 23;348(9039):1417-9
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Snippet The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We...
Background and Aims The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between...
Background and aimsThe association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different...
Background and Aims The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between...
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SubjectTerms Alanine
Alanine transaminase
Alleles
Analysis
Antigen presentation
Asian Continental Ancestry Group - genetics
Biology
Blood & organ donations
Blood transfusions
Carriers
Chromosomes
Chronic infection
Core protein
Deoxyribonucleic acid
DNA
Female
Genetic aspects
Genomes
Genotypes
Haplotypes
Health aspects
Hepatitis
Hepatitis B
Hepatitis B surface antigen
Hepatitis B, Chronic - genetics
Hepatology
Histocompatibility antigen HLA
Histocompatibility antigens
HLA histocompatibility antigens
HLA-DP Antigens - genetics
Hong Kong - epidemiology
Hospitals
Humans
Infection
Infections
Interferon
Laboratories
Liver cancer
Male
Medical research
Medicine
Medicine, Experimental
Middle Aged
Minority & ethnic groups
Polymorphism, Single Nucleotide
Population studies
Populations
Prevalence
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Tat protein
Virology
Viruses
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Title Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese
URI https://www.ncbi.nlm.nih.gov/pubmed/23825586
https://www.proquest.com/docview/1371431050
https://www.proquest.com/docview/1398433775
https://pubmed.ncbi.nlm.nih.gov/PMC3692552
https://doaj.org/article/b649caf4f32b4e7b9d5d74da3fabb377
http://dx.doi.org/10.1371/journal.pone.0066920
Volume 8
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