Promoter Methylation of MLH1, PMS2, MSH2 and p16 Is a Phenomenon of Advanced-Stage HCCs

• Published in: PloS one Vol. 9; no. 1; p. e84453
• Main Authors: Hinrichsen, Inga, Kemp, Matthias, Peveling-Oberhag, Jan, Passmann, Sandra, Plotz, Guido, Zeuzem, Stefan, Brieger, Angela
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.01.2014; Public Library of Science (PLoS)
• Subjects: Aberration; Adaptor Proteins, Signal Transducing - genetics; Adenosine Triphosphatases - genetics; Adult; Aged; Analysis; Biology; Biomedical research; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell cycle; Chemoresistance; Chemotherapy; Colorectal cancer; Cyclin-dependent kinase; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Deoxyribonucleic acid; DNA; DNA Methylation; DNA repair; DNA Repair Enzymes - genetics; DNA-Binding Proteins - genetics; Enzyme inhibitors; Epigenetic inheritance; Epigenetics; Female; Formaldehyde; Genes; Genetic aspects; Health aspects; Hepatitis; Hepatitis B; Hepatitis C; Hepatitis C virus; Hepatocellular carcinoma; Humans; Infection; Infections; Kinases; Laboratories; Liver; Liver cancer; Liver cirrhosis; Liver diseases; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Male; Medicine; Methylation; Microsatellite Instability; Middle Aged; Mismatch repair; Mismatch Repair Endonuclease PMS2; MLH1 protein; MSH2 protein; Mutation; MutL Protein Homolog 1; MutS Homolog 2 Protein - genetics; Neoplasm Grading; Neoplasm Staging; Nuclear Proteins - genetics; Paraffin; Promoter Regions, Genetic; Proteins; Tissue analysis; Tissues; Tumor suppressor genes; Tumors; Viruses; Germany

Epigenetic silencing of tumour suppressor genes has been observed in various cancers. Looking at hepatocellular carcinoma (HCC) specific protein silencing was previously demonstrated to be associated with the Hepatitis C virus (HCV). However, the proposed HCV dependent promoter methylation of DNA mi...