1H-NMR-Based Metabolic Analysis of Human Serum Reveals Novel Markers of Myocardial Energy Expenditure in Heart Failure Patients

• Published in: PloS one Vol. 9; no. 2; p. e88102
• Main Authors: Du, Zhiyong, Shen, Anna, Huang, Yuli, Su, Liang, Lai, Wenyan, Wang, Peng, Xie, Zhibing, Xie, Zhiquan, Zeng, Qingchun, Ren, Hao, Xu, Dingli
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.02.2014; Public Library of Science (PLoS)
• Subjects: 3-Hydroxybutyric Acid - blood; 3-Hydroxybutyric Acid - metabolism; Acetone; Acetone - blood; Acetone - metabolism; Adult; Aged; Aged, 80 and over; Angiotensin; Angiotensin converting enzyme; Angiotensin-converting enzyme inhibitors; Bioindicators; Biology; Biomarkers; Cardiology; Cardiovascular disease; Cardiovascular diseases; Chemistry; Coronary vessels; Dehydrogenases; Diabetes; Diuretics; Doppler effect; Echocardiography; Education; Energy expenditure; Energy Metabolism; Enzyme inhibitors; Failure analysis; Fatty acids; Female; Health aspects; Heart; Heart diseases; Heart failure; Heart Failure - blood; Heart Failure - metabolism; Heart Failure - pathology; Hospitals; Humans; Laboratories; Least squares method; Magnetic resonance; Male; Medicine; Metabolism; Metabolites; Metabolomics; Metabolomics - methods; Middle Aged; Mortality; Myocardium - metabolism; Myocardium - pathology; NMR; Nuclear magnetic resonance; Nuclear Magnetic Resonance, Biomolecular - methods; Oxidation; Patients; Peptidyl-dipeptidase A; Regression analysis; Serum - metabolism; Signal processing; Spectrum analysis; Statins; Succinic Acid - blood; Succinic Acid - metabolism; Tomography; Type 2 diabetes; Urine; Ventricle
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0088102

Elevated myocardial energy expenditure (MEE) is related with reduced left ventricular ejection fraction, and has also been documented as an independent predictor of cardiovascular mortality. However, the serum small-molecule metabolite profiles and pathophysiological mechanisms of elevated MEE in he...