Functional Advantages of Porphyromonas gingivalis Vesicles

• Published in: PloS one Vol. 10; no. 4; p. e0123448
• Main Authors: Ho, Meng-Hsuan, Chen, Chin-Ho, Goodwin, J. Shawn, Wang, Bing-Yan, Xie, Hua
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.04.2015; Public Library of Science (PLoS)
• Subjects: Atherosclerosis; Bacteria; Bacteroidaceae Infections - microbiology; Biofilms; Candida albicans; Cell Membrane; Cells, Cultured; Dentistry; Deoxyribonucleic acid; DNA; Endothelial cells; Extracellular Vesicles - physiology; Fibroblasts; Fibroblasts - microbiology; Fibroblasts - physiology; Gene Transfer, Horizontal; Genes, Bacterial; Gram-negative bacteria; Host-Pathogen Interactions; Human Umbilical Vein Endothelial Cells - microbiology; Human Umbilical Vein Endothelial Cells - physiology; Humans; Immune response; Keratinocytes - microbiology; Keratinocytes - physiology; Pathogens; Periodontics; Periodontitis - microbiology; Porphyromonas gingivalis; Porphyromonas gingivalis - physiology; Proteins; Pseudomonas aeruginosa; Ribonucleic acid; RNA; Vesicles; United States > US; Tennessee; Nashville Tennessee

Porphyromonas gingivalis is a keystone pathogen of periodontitis. Outer membrane vesicles (OMVs) have been considered as both offense and defense components of this bacterium. Previous studies indicated that like their originating cells, P. gingivalis vesicles, are able to invade oral epithelial cel...