Identification of the significant pathways of Banxia Houpu decoction in the treatment of depression based on network pharmacology

• Published in: PloS one Vol. 15; no. 9; p. e0239843
• Main Authors: Chen, Zi-ying, Xie, Dan-feng, Liu, Zhi-yuan, Zhong, Yong-qi, Zeng, Jing-yan, Chen, Zheng, Chen, Xin-lin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.09.2020; Public Library of Science (PLoS)
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Antidepressants; Biology and life sciences; Care and treatment; Chinese medicine; Computer and Information Sciences; Databases, Factual; Depression (Mood disorder); Depression - drug therapy; Depression - metabolism; Depression - pathology; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Encyclopedias; ErbB protein; Gene Ontology; Gene Regulatory Networks - drug effects; Genes; Genomes; Herbal medicine; Humans; Inflammation; MAP kinase; Medicine and Health Sciences; Medicine, Chinese Traditional; Mental depression; Metabolic Networks and Pathways - drug effects; Metabolism; Methods; Molecular modelling; Nutrition; Pharmacokinetics; Pharmacological research; Pharmacology; Protein Interaction Maps - drug effects; Research and Analysis Methods; Signal transduction; Signal Transduction - drug effects; Signaling; Software; Traditional Chinese medicine; China

Banxia Houpu decoction (BXHPD) has been used to treat depression in clinical practice for centuries. However, the pharmacological mechanisms of BXHPD still remain unclear. Network Pharmacology (NP) approach was used to explore the potential molecular mechanisms of BXHPD in treating depression. Poten...