Influence of APOE Genotype on Hippocampal Atrophy over Time - An N=1925 Surface-Based ADNI Study

• Published in: PloS one Vol. 11; no. 4; p. e0152901
• Main Authors: Li, Bolun, Shi, Jie, Gutman, Boris A., Baxter, Leslie C., Thompson, Paul M., Caselli, Richard J., Wang, Yalin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.04.2016; Public Library of Science (PLoS)
• Subjects: Aged; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Analysis; Apolipoprotein E4; Apolipoprotein E4 - genetics; Apolipoproteins; Atrophy; Atrophy - genetics; Atrophy - pathology; Automation; Biology and Life Sciences; Biomarkers; Brain research; Care and treatment; Carriers; Case-Control Studies; Consortia; Deformation; Dementia; Female; Genotype; Genotypes; Health risks; Heterozygote; Heterozygotes; Hippocampus; Hippocampus - pathology; Homozygote; Homozygotes; Humans; Informatics; Longitudinal Studies; Magnetic resonance imaging; Male; Medical imaging; Medicine and Health Sciences; Memory; Morphometry; Multivariate analysis; Neurodegenerative diseases; Neuroimaging; Neurology; NMR; Nuclear magnetic resonance; Physical Sciences; Research and Analysis Methods; Risk factors; Studies; Time Factors; Marina del Rey California; California; United States > US; Arizona

The apolipoprotein E (APOE) e4 genotype is a powerful risk factor for late-onset Alzheimer's disease (AD). In the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, we previously reported significant baseline structural differences in APOE e4 carriers relative to non-carriers, invo...