Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways

• Published in: PloS one Vol. 7; no. 12; p. e53176
• Main Authors: Li, Zheng, Shen, Jianxiong, Wu, William Ka Kei, Yu, Xin, Liang, Jinqian, Qiu, Guixing, Liu, Jiaming
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.12.2012; Public Library of Science (PLoS)
• Subjects: 1-Phosphatidylinositol 3-kinase; Aberration; AKT protein; Androstadienes - pharmacology; Back pain; Biology; Breast cancer; Butadienes - pharmacology; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Cells, Cultured; Cholecystokinin; Crosstalk; Cyclin D1; Cyclin D1 - genetics; Cyclin D1 - metabolism; Degeneration; Enzyme Inhibitors - pharmacology; Extracellular signal-regulated kinase; Hospitals; Humans; Immunocytochemistry; Intervertebral Disc - cytology; Intervertebral Disc - drug effects; Intervertebral Disc - metabolism; Intervertebral discs; Kinases; Leptin; Leptin - pharmacology; Leptin receptors; Medicine; Metabolic pathways; Microscopy; Mitogen-Activated Protein Kinase Kinases - genetics; Mitogen-Activated Protein Kinase Kinases - metabolism; Morphology; Nitriles - pharmacology; Nuclei; Nuclei (cytology); Nucleus pulposus; Obesity; Pathways; Pharmacology; Phosphorylation; Phosphorylation - drug effects; Proliferating cell nuclear antigen; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Receptors; Receptors, Leptin - genetics; Receptors, Leptin - metabolism; Rodents; Signal transduction; Signal Transduction - drug effects; Signaling; Stat3 protein; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Surgery; Tyrphostins - pharmacology; Up-Regulation - drug effects; Wortmannin; Beijing China; China

Increasing evidence suggests that obesity and aberrant proliferation of nucleus pulposus (NP) cells are associated with intervertebral disc degeneration. Leptin, a hormone with increased circulating level in obesity, has been shown to stimulate cell proliferation in a tissue-dependent manner. Nevert...