Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways - Li, Zheng; Shen, Jianxiong; Wu, William Ka Kei; Yu, Xin; Liang, Jinqian; Qiu, Guixing; Liu, Jiaming (PloS one, 2012)
Keywords: 1-Phosphatidylinositol 3-kinase; Aberration; AKT protein; Androstadienes - pharmacology; Back pain; Biology; Breast cancer; Butadienes - pharmacology; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Cells, Cultured; Cholecystokinin; Crosstalk; Cyclin D1; Cyclin D1 - genetics; Cyclin D1 - metabolism; Degeneration; Enzyme Inhibitors - pharmacology; Extracellular signal-regulated kinase; Hospitals; Humans; Immunocytochemistry; Intervertebral Disc - cytology; Intervertebral Disc - drug effects; Intervertebral Disc - metabolism; Intervertebral discs; Kinases; Leptin; Leptin - pharmacology; Leptin receptors; Medicine; Metabolic pathways; Microscopy; Mitogen-Activated Protein Kinase Kinases - genetics; Mitogen-Activated Protein Kinase Kinases - metabolism; Morphology; Nitriles - pharmacology; Nuclei; Nuclei (cytology); Nucleus pulposus; Obesity; Pathways; Pharmacology; Phosphorylation; Phosphorylation - drug effects; Proliferating cell nuclear antigen; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Receptors; Receptors, Leptin - genetics; Receptors, Leptin - metabolism; Rodents; Signal transduction; Signal Transduction - drug effects; Signaling; Stat3 protein; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Surgery; Tyrphostins - pharmacology; Up-Regulation - drug effects; Wortmannin; Beijing China; China