Proangiogenic Compositions of Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells

• Published in: PloS one Vol. 9; no. 12; p. e115316
• Main Authors: Chen, Jianying, Liu, Zhenjun, Hong, Mian Ming, Zhang, Hongzhe, Chen, Can, Xiao, Mengyuan, Wang, Junxian, Yao, Feng, Ba, Mingchuan, Liu, Jinghu, Guo, Zi-Kuan, Zhong, Jixin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.12.2014; Public Library of Science (PLoS)
• Subjects: Analysis; Analysis of Variance; Angiogenesis; Angiogenin; Apoptosis; Biology and Life Sciences; Biomolecules; Blotting, Western; Cardiovascular disease; CD29 antigen; CD44 antigen; CD45 antigen; CD73 antigen; Cell culture; Chemokine CCL2 - metabolism; Cytokines; Cytokines - metabolism; Deprivation; Fibroblast growth factor 2; Fibroblast growth factors; Growth factors; Hospitals; Human subjects; Humans; Hypoxia; Hypoxia - physiopathology; Immunoglobulins; Insulin-like growth factors; Interleukin 6; Internal medicine; Ischemia; Medicine; Medicine and Health Sciences; Mesenchymal stem cells; Mesenchymal Stromal Cells - physiology; Mesenchyme; Microscopy, Electron, Scanning; Microvessels - physiology; Microvessels - ultrastructure; Monocyte chemoattractant protein 1; Neovascularization, Physiologic - physiology; Ribonuclease, Pancreatic - metabolism; Stem cells; U-Plasminogen activator; Umbilical cord; Umbilical Cord - cytology; Urokinase; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Beijing China; United States > US; China

Microvesicles (MVs) derived from mesenchymal stem cells (MSCs) have been shown to promote angiogenesis. This study was aimed to shed a light on the mechanisms by analyzing the angiogenesis-promoting compositions of MSC-MVs. Also we try to figure out the impact of hypoxia on angiogenesis. MVs were is...