Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects

• Published in: PloS one Vol. 11; no. 2; p. e0147468
• Main Authors: Latorre, Rocco, Huynh, Jennifer, Mazzoni, Maurizio, Gupta, Arpana, Bonora, Elena, Clavenzani, Paolo, Chang, Lin, Mayer, Emeran A., De Giorgio, Roberto, Sternini, Catia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.02.2016; Public Library of Science (PLoS)
• Subjects: Adult; Antibodies; Biology and Life Sciences; Bitter taste; Body mass; Body weight; Cholecystokinin; Cholecystokinin - analysis; Chromogranin A - analysis; Colon; Colon - chemistry; Colon - cytology; Colon - pathology; Diabetes; Disease; Energy balance; Enteroendocrine Cells - metabolism; Family medical history; Female; Food; Gene expression; Glucagon; Glucagon-Like Peptide 1 - analysis; High fat diet; Humans; Immunohistochemistry; Intestinal Mucosa - chemistry; Intestinal Mucosa - cytology; Male; Medicine; Medicine and Health Sciences; Middle Aged; mRNA; Mucosa; Neurobiology; Neurosciences; Obesity; Obesity - metabolism; Obesity - pathology; Overweight; Overweight - metabolism; Overweight - pathology; Peptide YY - analysis; Polymerase chain reaction; Population (statistical); Proteins; Receptors; Receptors, G-Protein-Coupled - analysis; Receptors, G-Protein-Coupled - biosynthesis; Receptors, G-Protein-Coupled - genetics; Research and Analysis Methods; RNA; RNA, Messenger - biosynthesis; Rodents; Social Sciences; Taste; Taste receptors; Viral antibodies; Young Adult; Los Angeles California; California; United States > US; Oklahoma

Bitter taste receptors (T2Rs) are expressed in the mammalian gastrointestinal mucosa. In the mouse colon, T2R138 is localized to enteroendocrine cells and is upregulated by long-term high fat diet that induces obesity. The aims of this study were to test whether T2R38 expression is altered in overwe...