Oncolytic Reovirus in Canine Mast Cell Tumor

• Published in: PloS one Vol. 8; no. 9; p. e73555
• Main Authors: Hwang, Chung Chew, Umeki, Saori, Kubo, Masahito, Hayashi, Toshiharu, Shimoda, Hiroshi, Mochizuki, Masami, Maeda, Ken, Baba, Kenji, Hiraoka, Hiroko, Coffey, Matt, Okuda, Masaru, Mizuno, Takuya
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.09.2013; Public Library of Science (PLoS)
• Subjects: Adenoviruses; Animal models; Animals; Apoptosis; Biotechnology; Blotting, Western; Bone marrow; Cancer; Cancer therapies; Cell death; Clinical trials; Dog Diseases - therapy; Dogs; Humans; Immunotherapy; In vivo methods and tests; Infections; Internal medicine; Kinases; Laboratories; Mast cells; Mast Cells - pathology; Mast Cells - virology; Mastocytosis - therapy; Medical research; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Mutation; Oncolysis; Oncolytic Virotherapy; Pets; Principal components analysis; Progeny; Proteins; Reoviridae - physiology; Science; Skin cancer; Tumor Cells, Cultured; Tumors; Veterinary medicine; Virus Replication; Viruses; Xenograft Model Antitumor Assays; Xenografts; Japan

The usage of reovirus has reached phase II and III clinical trials in human cancers. However, this is the first study to report the oncolytic effects of reovirus in veterinary oncology, focusing on canine mast cell tumor (MCT), the most common cutaneous tumor in dogs. As human and canine cancers sha...