Clinical Disease Severity of Respiratory Viral Co-Infection versus Single Viral Infection: A Systematic Review and Meta-Analysis

• Published in: PloS one Vol. 9; no. 6; p. e99392
• Main Authors: Asner, Sandra A., Science, Michelle E., Tran, Dat, Smieja, Marek, Merglen, Arnaud, Mertz, Dominik
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.06.2014; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Bias; Child; Child Mortality; Child, Preschool; Children; Coinfection - epidemiology; Humans; Illnesses; Infant; Infection; Infections; Intensive Care Units - statistics & numerical data; Length of Stay - statistics & numerical data; Medicine and Health Sciences; Meta-analysis; Middle Aged; Mortality; Mortality risk; Observational studies; Observational Studies as Topic - statistics & numerical data; Observer Variation; Oxygen; Oxygen requirement; Oxygen requirements; Preschool children; Quality; Respiratory diseases; Respiratory Tract Infections - epidemiology; Subgroups; Systematic review; Viral infections; Virulence; Virus Diseases - epidemiology; Viruses; Young Adult

Results from cohort studies evaluating the severity of respiratory viral co-infections are conflicting. We conducted a systematic review and meta-analysis to assess the clinical severity of viral co-infections as compared to single viral respiratory infections. We searched electronic databases and o...