Osteocytic Protein Expression Response to Doxercalciferol Therapy in Pediatric Dialysis Patients

• Published in: PloS one Vol. 10; no. 3; p. e0120856
• Main Authors: Pereira, Renata C., Jüppner, Harald, Gales, Barbara, Salusky, Isidro B., Wesseling-Perry, Katherine
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.03.2015; Public Library of Science (PLoS)
• Subjects: Adaptor Proteins, Signal Transducing; Adolescent; Biocompatibility; Biopsy; Bone and Bones - drug effects; Bone and Bones - metabolism; Bone and Bones - pathology; Bone Density Conservation Agents - pharmacology; Bone Density Conservation Agents - therapeutic use; Bone growth; Bone Morphogenetic Proteins - genetics; Bone Morphogenetic Proteins - metabolism; Child; Chronic kidney failure; Dentin; Dialysis; Dmp1 protein; Ergocalciferols - pharmacology; Ergocalciferols - therapeutic use; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; Fibroblast growth factor 23; Fibroblast growth factors; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Fibroblasts; Fragments; Gene Expression; Genetic Markers - genetics; Growth factors; Homeostasis; Humans; Immunohistochemistry; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Long bone; Male; Medicine; Metabolism; Mineral metabolism; Mineralization; Mutation; Osteocytes - metabolism; Osteolysis - blood; Osteolysis - drug therapy; Osteolysis - genetics; Osteolysis - metabolism; Parathyroid hormone; Parathyroid hormones; Patients; Pediatrics; Peritoneal dialysis; Phosphoproteins - genetics; Phosphoproteins - metabolism; Phosphorus; Physiological aspects; Protein expression; Proteins; Renal Dialysis - adverse effects; Rodents; SOST protein; Sterols; Therapy; Treatment Outcome; Values; Vitamin D; Los Angeles California; San Clemente California; California; United States > US; Massachusetts

Osteocytic protein expression is dysregulated in CKD and is affected by changes in mineral metabolism; however the effects of active vitamin D sterol therapy on osteocyte protein expression in advanced CKD is unknown. Eleven pediatric patients with end stage kidney disease underwent bone biopsy, wer...