Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion

• Published in: PloS one Vol. 10; no. 11; p. e0140903
• Main Authors: Wall, Benjamin Toby, Gorissen, Stefan H., Pennings, Bart, Koopman, René, Groen, Bart B. L., Verdijk, Lex B., van Loon, Luc J. C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.11.2015; Public Library of Science (PLoS)
• Subjects: Absorptivity; Aged; Aging; Care and treatment; Cross-Sectional Studies; Development and progression; Diet; Dietary Proteins - metabolism; Global health; Humans; In vivo methods and tests; Ingestion; Laboratories; Male; Men; Muscle Proteins - metabolism; Muscles; Nanowires; Nutrition; Patient outcomes; Postprandial Period; Protein biosynthesis; Protein Biosynthesis - physiology; Protein folding; Protein synthesis; Retrospective Studies; Sarcopenia; Sarcopenia - metabolism; Sarcopenia - pathology; Skeletal muscle; Stable isotopes; Young Adult; United States; Netherlands

Progressive loss of skeletal muscle mass with aging (sarcopenia) forms a global health concern. It has been suggested that an impaired capacity to increase muscle protein synthesis rates in response to protein intake is a key contributor to sarcopenia. We assessed whether differences in post-absorpt...