Characterization of a Surface Glycoprotein from Echinococcus multilocularis and Its Mucosal Vaccine Potential in Dogs

• Published in: PloS one Vol. 8; no. 7; p. e69821
• Main Authors: Kouguchi, Hirokazu, Matsumoto, Jun, Nakao, Ryo, Yamano, Kimiaki, Oku, Yuzaburo, Yagi, Kinpei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.07.2013; Public Library of Science (PLoS)
• Subjects: Administration, Intranasal; Alveoli; Analysis; Animals; Antibody response; Antigens; Antigens, Helminth - immunology; Biology; Cholera; Cholera toxin; Disease prevention; Disease susceptibility; Dog Diseases - immunology; Dog Diseases - parasitology; Dog Diseases - prevention & control; Dogs; Echinococcosis; Echinococcosis, Hepatic - immunology; Echinococcosis, Hepatic - parasitology; Echinococcosis, Hepatic - prevention & control; Echinococcosis, Hepatic - veterinary; Echinococcus; Echinococcus granulosus; Echinococcus multilocularis; Echinococcus multilocularis - immunology; Female; Foxes; Gel filtration; Glycoproteins; Glycosylation; Health aspects; Health risks; Immunization; Immunoglobulin A; Immunoglobulin A - immunology; Immunology; Infections; Infectious diseases; Intestine; Intestine, Small - parasitology; Laboratory animals; Life cycle engineering; Life cycles; Medicine; Membrane Glycoproteins - immunology; Membrane Glycoproteins - isolation & purification; Mucin; Mucosa; Nippostrongylus brasiliensis; Parasites; Prevention programs; Public health; Rodents; Studies; Surface antigens; Toxins; Tropical diseases; Two dimensional analysis; Vaccines; Vaccines - immunology; Veterinary Science; Waterborne diseases; Worms; Zoonoses; Japan

Alveolar echinococcosis is a refractory disease caused by the metacestode stage of Echinococcus multilocularis. The life cycle of this parasite is maintained primarily between foxes and many species of rodents; thus, dogs are thought to be a minor definitive host except in some endemic areas. Howeve...