Identification and Characterization of Sebaceous Gland Atrophy-Sparing DGAT1 Inhibitors

• Published in: PloS one Vol. 9; no. 2; p. e88908
• Main Authors: Muise, Eric S., Zhu, Yonghua, Verras, Andreas, Karanam, Bindhu V., Gorski, Judith, Weingarth, Drew, Lin, Hua V., Hwa, Joyce, Thompson, John R., Hu, Guanghui, Liu, Jian, He, Shuwen, DeVita, Robert J., Shen, Dong-Ming, Pinto, Shirly
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2014; Public Library of Science (PLoS)
• Subjects: Animals; Atrophy; Atrophy - chemically induced; Atrophy - enzymology; Biology; Biomarkers; Biomarkers - metabolism; Biosynthesis; Chemistry; Diabetes; Diacylglycerol; Diacylglycerol O-acyltransferase; Diacylglycerol O-Acyltransferase - antagonists & inhibitors; Diglycerides; Drug Discovery; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - pharmacology; Hydrophobic and Hydrophilic Interactions; Inhibition; Inhibitors; Laboratories; Lipids; Male; Medicine; Metabolic disorders; Metabolic pathways; Metabolism; Mice; Obesity; Peptides; Pharmaceutical industry; Pharmacology; Physical properties; R&D; Research & development; Ribonucleic acid; RNA; Rodents; Sebaceous gland; Sebaceous Glands - drug effects; Sebaceous Glands - pathology; Skin; Skin - drug effects; Skin - enzymology; Skin - metabolism; Small Molecule Libraries - adverse effects; Small Molecule Libraries - chemistry; Small Molecule Libraries - metabolism; Small Molecule Libraries - pharmacology; Tissues; Vaccines; United States > US; New Jersey

Inhibition of Diacylglycerol O-acyltransferase 1 (DGAT1) has been a mechanism of interest for metabolic disorders. DGAT1 inhibition has been shown to be a key regulator in an array of metabolic pathways; however, based on the DGAT1 KO mouse phenotype the anticipation is that pharmacological inhibiti...