Myocardial global longitudinal strain: An early indicator of cardiac interstitial fibrosis modified by spironolactone, in a unique hypertensive rat model

• Published in: PloS one Vol. 14; no. 8; p. e0220837
• Main Authors: Leader, Catherine J., Moharram, Mohammed, Coffey, Sean, Sammut, Ivan A., Wilkins, Gerard W., Walker, Robert J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.08.2019; Public Library of Science (PLoS)
• Subjects: Animal genetic engineering; Animal models; Animals; Antiandrogens; Biology and Life Sciences; Blood pressure; Cardiotonic Agents - therapeutic use; Cardiovascular disease; Care and treatment; Comparative analysis; Complications and side effects; Development and progression; Diagnosis; Disease Models, Animal; Drug dosages; Echocardiography; Endomyocardial Fibrosis - drug therapy; Endomyocardial Fibrosis - etiology; Endomyocardial Fibrosis - pathology; Endomyocardial Fibrosis - physiopathology; Fibrosis; Genetic engineering; Heart; Heart failure; Heart hypertrophy; Hypertension; Hypertension - complications; Hypertension - diagnostic imaging; Hypertension - physiopathology; Hypertrophy; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - physiopathology; Longitude; Male; Medicine; Medicine and Health Sciences; Methods; Mortality; Rats; Rats, Transgenic; Research and Analysis Methods; Rodents; Spironolactone; Spironolactone - therapeutic use; Stroke Volume; Studies; Systematic review; Testing; Ventricle; Ventricular Function, Left; New Zealand

Is global longitudinal strain (GLS) a more accurate non-invasive measure of histological myocardial fibrosis than left ventricular ejection fraction (LVEF) in a hypertensive rodent model. Hypertension results in left ventricular hypertrophy and cardiac dysfunction. Speckle-tracking echocardiography...