Myocardial global longitudinal strain: An early indicator of cardiac interstitial fibrosis modified by spironolactone, in a unique hypertensive rat model - Leader, Catherine J.; Moharram, Mohammed; Coffey, Sean; Sammut, Ivan A.; Wilkins, Gerard W.; Walker, Robert J. (PloS one, 2019)
Keywords: Animal genetic engineering; Animal models; Animals; Antiandrogens; Biology and Life Sciences; Blood pressure; Cardiotonic Agents - therapeutic use; Cardiovascular disease; Care and treatment; Comparative analysis; Complications and side effects; Development and progression; Diagnosis; Disease Models, Animal; Drug dosages; Echocardiography; Endomyocardial Fibrosis - drug therapy; Endomyocardial Fibrosis - etiology; Endomyocardial Fibrosis - pathology; Endomyocardial Fibrosis - physiopathology; Fibrosis; Genetic engineering; Heart; Heart failure; Heart hypertrophy; Hypertension; Hypertension - complications; Hypertension - diagnostic imaging; Hypertension - physiopathology; Hypertrophy; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - physiopathology; Longitude; Male; Medicine; Medicine and Health Sciences; Methods; Mortality; Rats; Rats, Transgenic; Research and Analysis Methods; Rodents; Spironolactone; Spironolactone - therapeutic use; Stroke Volume; Studies; Systematic review; Testing; Ventricle; Ventricular Function, Left; New Zealand