Traumatic Brain Injury Dysregulates MicroRNAs to Modulate Cell Signaling in Rat Hippocampus

• Published in: PloS one Vol. 9; no. 8; p. e103948
• Main Authors: Liu, Liang, Sun, Tingyi, Liu, Zilong, Chen, Xiaorui, Zhao, Lili, Qu, Guoqiang, Li, Qingjie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.08.2014; Public Library of Science (PLoS)
• Subjects: alpha-Synuclein - genetics; alpha-Synuclein - metabolism; Animal cognition; Animals; Apoptosis; Biological activity; Biology and Life Sciences; Brain; Brain damage; Brain injuries; Brain Injuries - genetics; Brain Injuries - metabolism; Brain Injuries - pathology; Calcium; Calcium-binding protein; Calmodulin; Cell interactions; Cognitive ability; Damage assessment; Dementia; DNA microarrays; Epigenesis, Genetic; Epigenetic inheritance; Female; Forensic medicine; Gender; Gene expression; Gene Expression Profiling; Gene Regulatory Networks; Genes; Genetic engineering; Guanylate Kinases - genetics; Guanylate Kinases - metabolism; Head injuries; Hippocampus; Hippocampus - injuries; Hippocampus - metabolism; Hippocampus - pathology; Immunological memory; Injury analysis; Kinases; Laboratory animals; Male; Medical research; Medicine and Health Sciences; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular Sequence Annotation; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Oligonucleotide Array Sequence Analysis; Parkinson's disease; Pathogenesis; Polymerase chain reaction; Protein kinase; Proteins; Rats; Rats, Sprague-Dawley; Research and Analysis Methods; Ribonucleic acid; RNA; Rodents; Science; Signal Transduction; Signaling; Spatial discrimination learning; Spatial memory; Synapses; Synapses - genetics; Synapses - metabolism; Synapses - pathology; Synapses - ultrastructure; Synuclein; Time Factors; Traumatic brain injury; Ultrastructure; Western blotting; China

Traumatic brain injury (TBI) is a common cause for cognitive and communication problems, but the molecular and cellular mechanisms are not well understood. Epigenetic modifications, such as microRNA (miRNA) dysregulation, may underlie altered gene expression in the brain, especially hippocampus that...