A Semi-Physiologically Based Pharmacokinetic Pharmacodynamic Model for Glycyrrhizin-Induced Pseudoaldosteronism and Prediction of the Dose Limit Causing Hypokalemia in a Virtual Elderly Population - Xu, Ruijuan; Liu, Xiaoquan; Yang, Jin (PloS one, 2014)
Keywords: Acids; Aldosterone; Angiotensin; Angiotensin II; Angiotensins; Animals; Biology and Life Sciences; Computer Simulation; Cortisol; Cortisone; Dehydrogenases; Drug dosages; Enzymes; Excretion; Exposure; Food additives; Geriatrics; Glycyrrhizic Acid - adverse effects; Glycyrrhizic Acid - pharmacokinetics; Glycyrrhizin; Hormones; Humans; Hypertension; Hypokalemia; Hypokalemia - chemically induced; Kidneys; Laboratories; Liddle Syndrome - chemically induced; Liddle Syndrome - metabolism; Male; Mathematical models; Medicine and Health Sciences; Metabolism; Metabolites; Microbiota; Monte Carlo Method; Monte Carlo methods; Monte Carlo simulation; Older people; Pharmaceuticals; Pharmacodynamics; Pharmacokinetics; Pharmacology; Plasma levels; Potassium; Probability distribution; Rats; Rats, Sprague-Dawley; Renin; Risk Assessment; Rodents; Scaling; Scaling factors; Sodium; China