Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways - Huang, Wei-Ru; Chiu, Hung-Chuan; Liao, Tsai-Ling; Chuang, Kuo-Pin; Shih, Wing-Ling; Liu, Hung-Jen (PloS one, 2015)
Keywords: 1-Phosphatidylinositol 3-kinase; Accumulation; Activation; Agricultural biotechnology; AKT protein; Amino Acid Sequence; Animal vaccines; Animals; Apoptosis; Arrestin; Autophagy; Cell cycle; Cell Line; Cellular signal transduction; Cercopithecus aethiops; Cyclin D1; Cyclin-dependent kinase 4; Cyclin-dependent kinase inhibitor p21; Cytoplasm; Deactivation; Extracellular signal-regulated kinase; Genomes; Health aspects; Hepatitis; Host-Pathogen Interactions; Humans; Inactivation; Infections; Kinases; Localization; MAP Kinase Signaling System; Molecular biology; Nuclear Localization Signals; Nuclear Pore Complex Proteins - analysis; Nuclear Pore Complex Proteins - metabolism; Nuclei; Orthoreovirus, Avian - physiology; p53 Protein; Phagocytosis; Phosphatase; Phosphatidylinositol 3-Kinases - analysis; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Physiological aspects; Porins; Protein Interaction Maps; Proteins; Proto-Oncogene Proteins c-akt - analysis; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - metabolism; PTEN protein; Reoviridae Infections - metabolism; Reoviridae Infections - pathology; Reoviruses; Senescence; Signal Transduction; Signaling; TOR protein; TOR Serine-Threonine Kinases - metabolism; Transcription; Transcription factors; Translocation; Tumor proteins; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - metabolism; Ubiquitin-protein ligase; Vero Cells; Viral infections; Viral Proteins - analysis; Viral Proteins - metabolism; Viruses; Taiwan; United States--US