Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models

• Published in: PloS one Vol. 11; no. 2; p. e0148184
• Main Authors: Kotani, Osamu, Naeem, Asif, Suzuki, Tadaki, Iwata-Yoshikawa, Naoko, Sato, Yuko, Nakajima, Noriko, Hosomi, Takushi, Tsukagoshi, Hiroyuki, Kozawa, Kunihisa, Hasegawa, Hideki, Taguchi, Fumihiro, Shimizu, Hiroyuki, Nagata, Noriyo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2016; Public Library of Science (PLoS)
• Subjects: Adaptation; Amino Acid Sequence; Amino acids; Animal models; Animals; Animals, Newborn; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antigens, Viral - immunology; Aseptic meningitis; Binding sites; Biology and Life Sciences; Body Weight; Brain; Brain - pathology; Brain - virology; Cardiovirus - immunology; Cardiovirus - isolation & purification; Cardiovirus - pathogenicity; Cardiovirus Infections - genetics; Cardiovirus Infections - immunology; Cardiovirus Infections - pathology; Cardiovirus Infections - virology; Cells (biology); Cerebellum; Children; Clinical isolates; Demyelinating Diseases - pathology; Demyelination; Development and progression; Disease Models, Animal; Disease Progression; Encephalitis; Enterovirus; Environmental science; Epithelial cells; Female; Genetic aspects; Glial cells; Glial stem cells; Health surveillance; Immunity; Immunology; Infections; Infectious diseases; Infectivity; Inflammation; Inflammation - pathology; Injections, Intraventricular; Inoculation; Interferon Type I - metabolism; Life sciences; Medicine and Health Sciences; Meningitis; Mice; Mice, Inbred BALB C; Mucosa; Mucous Membrane - pathology; Mucous Membrane - virology; Neonates; Neural stem cells; Neurological disorders; Neuronal-glial interactions; Neurons; Neuropathology; Neurotropism; Neurovirulence; Newborn babies; Paralysis; Pathology; Physiological aspects; Picornaviridae; Picornavirus infections; Picornaviruses; Poliomyelitis; Polyproteins; Proteins; Public health; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Rodents; Spinal cord; Strains (organisms); Surveillance; Tropism; Veterinary medicine; Viral infections; Virology; Virulence; Virus Replication; Viruses; West Nile virus; Japan

Saffold virus (SAFV), a picornavirus, is occasionally detected in children with acute flaccid paralysis, meningitis, and cerebellitis; however, the neuropathogenicity of SAFV remains undetermined. The virulence of two clinical isolates of SAFV type 3 (SAFV-3) obtained from a patient with aseptic men...