Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study

• Published in: PloS one Vol. 10; no. 7; p. e0133159
• Main Authors: Kitagawa, Hiroyuki, Munekage, Masaya, Matsumoto, Takashi, Sadakane, Chiharu, Fukutake, Miwako, Aoki, Katsuyuki, Watanabe, Junko, Maemura, Kazuya, Hattori, Tomohisa, Kase, Yosio, Uezono, Yasuhito, Inui, Akio, Hanazaki, Kazuhiro
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.07.2015; Public Library of Science (PLoS)
• Subjects: Acids; Adult; Anorexia; Carboxylic acids; Chalcones - analysis; Citrus fruits; Confidence intervals; Drug dosages; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - adverse effects; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacokinetics; Dyspepsia; Exposure; Female; Flavonoids - analysis; Fruit juices; Gastroesophageal reflux; Gastrointestinal diseases; Gastrointestinal tract diseases; Ghrelin; Healthy Volunteers; Hesperidin - analysis; Human subjects; Humans; Ingredients; Laboratories; Liquiritigenin; Male; Metabolism; Metabolites; Naringenin; Oral administration; Pharmaceutical industry; Pharmacokinetics; Pharmacology; Plasma; Randomization; Serotonin; Studies; Surgery; Traditional medicine; Triterpenes - analysis; Urine

Rikkunshito, a traditional Japanese (Kampo) medicine, has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux. This study investigated the exposure and pharmacokinetics of the ingredients of rikkunshito in healthy volunteers. First, an explora...