Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study - Kitagawa, Hiroyuki; Munekage, Masaya; Matsumoto, Takashi; Sadakane, Chiharu; Fukutake, Miwako; Aoki, Katsuyuki; Watanabe, Junko; Maemura, Kazuya; Hattori, Tomohisa; Kase, Yosio; Uezono, Yasuhito; Inui, Akio; et al. (PloS one, 2015)
Keywords: Acids; Adult; Anorexia; Carboxylic acids; Chalcones - analysis; Citrus fruits; Confidence intervals; Drug dosages; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - adverse effects; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacokinetics; Dyspepsia; Exposure; Female; Flavonoids - analysis; Fruit juices; Gastroesophageal reflux; Gastrointestinal diseases; Gastrointestinal tract diseases; Ghrelin; Healthy Volunteers; Hesperidin - analysis; Human subjects; Humans; Ingredients; Laboratories; Liquiritigenin; Male; Metabolism; Metabolites; Naringenin; Oral administration; Pharmaceutical industry; Pharmacokinetics; Pharmacology; Plasma; Randomization; Serotonin; Studies; Surgery; Traditional medicine; Triterpenes - analysis; Urine