Feedbacks from the metabolic network to the genetic network reveal regulatory modules in E. coli and B. subtilis

• Published in: PloS one Vol. 13; no. 10; p. e0203311
• Main Authors: Kumar, Santhust, Mahajan, Saurabh, Jain, Sanjay
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.10.2018; Public Library of Science (PLoS)
• Subjects: Analysis; Astrophysics; Biology; Biology and Life Sciences; Biotechnology; Cell division; Chemical reactions; Computer and Information Sciences; Computer simulation; Control; E coli; Environmental changes; Environmental conditions; Enzymes; Escherichia coli; Feedback; Gene expression; Genes; Genetic regulation; Medicine and Health Sciences; Metabolism; Metabolites; Modules; Research and Analysis Methods; RNA polymerase; Studies; Transcription factors; United States > US; India

The genetic regulatory network (GRN) plays a key role in controlling the response of the cell to changes in the environment. Although the structure of GRNs has been the subject of many studies, their large scale structure in the light of feedbacks from the metabolic network (MN) has received relativ...