Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus

Bacterial interference creates an ecological competition between commensal and pathogenic bacteria. Through fermentation of milk with gut-friendly bacteria, yogurt is an excellent aid to balance the bacteriological ecosystem in the human intestine. Here, we demonstrate that fermentation of glycerol...

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Published inPloS one Vol. 8; no. 2; p. e55380
Main Authors Shu, Muya, Wang, Yanhan, Yu, Jinghua, Kuo, Sherwin, Coda, Alvin, Jiang, Yong, Gallo, Richard L, Huang, Chun-Ming
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 06.02.2013
Public Library of Science (PLoS)
Subjects
Acne
Animals
Antibiotics
Bacteria
Bacterial infections
Biology
Commensals
Communicable diseases
Dermatology
Drug resistance
Fatty acids
Fermentation
Gene expression
Glycerol
Glycerol - metabolism
Humans
Hydrogen-Ion Concentration
Infectious diseases
Intestine
Lipids
Mathematics
Medical research
Medicine
Methicillin
Methicillin-Resistant Staphylococcus aureus - genetics
Methicillin-Resistant Staphylococcus aureus - metabolism
Mice
Mice, Inbred ICR
Microbial drug resistance
Microbiota
Microorganisms
Milk
Prevention
Probiotics
Probiotics - metabolism
Propionibacterium acnes
Propionibacterium acnes - genetics
Propionibacterium acnes - metabolism
Skin
Skin - metabolism
Skin - microbiology
Skin diseases
Skin resistance
Staphylococcal Skin Infections - metabolism
Staphylococcal Skin Infections - microbiology
Staphylococcal Skin Infections - prevention & control
Staphylococcus aureus
Staphylococcus aureus - metabolism
Staphylococcus aureus infections
Staphylococcus infections
Yogurt
La Jolla California
United States > US
California
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Summary:Bacterial interference creates an ecological competition between commensal and pathogenic bacteria. Through fermentation of milk with gut-friendly bacteria, yogurt is an excellent aid to balance the bacteriological ecosystem in the human intestine. Here, we demonstrate that fermentation of glycerol with Propionibacterium acnes (P. acnes), a skin commensal bacterium, can function as a skin probiotic for in vitro and in vivo growth suppression of USA300, the most prevalent community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). We also promote the notion that inappropriate use of antibiotics may eliminate the skin commensals, making it more difficult to fight pathogen infection. This study warrants further investigation to better understand the role of fermentation of skin commensals in infectious disease and the importance of the human skin microbiome in skin health.
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Conceived and designed the experiments: CHM. Performed the experiments: MS YW CMH JY SK. Analyzed the data: AC YJ CMH. Contributed reagents/materials/analysis tools: RLG CMH. Wrote the paper: CMH.
Competing Interests: The authors would like to declare the affiliation(s) to Surface Bioadvances Inc. The manuscript did not have the affiliations to Surface Bioadvances Inc. in terms of employment, consultancy, patents, products in development or marketed products. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0055380