Wolbachia infection modifies the profile, shuttling and structure of microRNAs in a mosquito cell line

• Published in: PloS one Vol. 9; no. 4; p. e96107
• Main Authors: Mayoral, Jaime G, Etebari, Kayvan, Hussain, Mazhar, Khromykh, Alexander A, Asgari, Sassan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Aedes - genetics; Aedes - microbiology; Aedes aegypti; Analysis; Animal reproduction; Animals; Anopheles stephensi; Aquatic insects; Argonaute Proteins - genetics; Biological activity; Biology and life sciences; Cell Line; Cell lines; Cell Nucleus - genetics; Comparative analysis; Compartments; Cytoplasm; Cytoplasm - genetics; Drosophila; Gene expression; Gene Expression Regulation; Gene sequencing; Genetic aspects; Genetic engineering; Genomes; Genomics; Health aspects; High-Throughput Nucleotide Sequencing; Host-Pathogen Interactions; Immune response; Immune system; Infections; Infectious diseases; Insect Proteins - genetics; Insects; Machinery and equipment; Malaria; Medicine and Health Sciences; MicroRNA; MicroRNAs; MicroRNAs - chemistry; MicroRNAs - genetics; miRNA; Molecular Sequence Data; Mosquitoes; Nuclei; Nuclei (cytology); Nucleotides; Physiological aspects; Ribonucleic acid; RNA; RNA polymerase; RNA Transport; Signaling; Target recognition; Wolbachia; Wolbachia - physiology

MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in many biological processes such as development, cell signaling and immune response. Small RNA deep sequencing technology provided an opportunity for a thorough survey of the miRNA profile of a mosquito cell line from Aedes aegy...