An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans

• Published in: Carcinogenesis (New York) Vol. 28; no. 3; pp. 625 - 631
• Main Authors: Bonassi, Stefano, Znaor, Ariana, Ceppi, Marcello, Lando, Cecilia, Chang, Wushou Peter, Holland, Nina, Kirsch-Volders, Micheline, Zeiger, Errol, Ban, Sadayuki, Barale, Roberto, Bigatti, Maria Paola, Bolognesi, Claudia, Cebulska-Wasilewska, Antonina, Fabianova, Eleonora, Fucic, Alexandra, Hagmar, Lars, Joksic, Gordana, Martelli, Antonietta, Migliore, Lucia, Mirkova, Ekaterina, Scarfi, Maria Rosaria, Zijno, Andrea, Norppa, Hannu, Fenech, Michael
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2007; Oxford Publishing Limited (England)
• Subjects: Biological and medical sciences; Biomarkers; Cancer and Oncology; Cancer och onkologi; Carcinogenesis, carcinogens and anticarcinogens; Clinical Medicine; DNA Damage; Europe; Female; Humans; Japan; Klinisk medicin; Lymphocytes - pathology; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Micronucleus Tests; Neoplasms - epidemiology; Occupational Exposure - statistics & numerical data; Risk Factors; Smoking - epidemiology; Taiwan; Tumors; Europe; Japan; Taiwan; Human; Risk factor; Micronucleus; Frequency; Malignant tumor; Predictive factor; Epidemiology; Lymphocyte; Blood; Cancer

The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospe...