Downregulated miR-195 Detected in Preeclamptic Placenta Affects Trophoblast Cell Invasion via Modulating ActRIIA Expression

• Published in: PloS one Vol. 7; no. 6; p. e38875
• Main Authors: Bai, Yang, Yang, Weiwei, Yang, Hui-xia, Liao, Qinping, Ye, Gang, Fu, Guodong, Ji, Lei, Xu, Peng, Wang, Hao, Li, Yu-xia, Peng, Chun, Wang, Yan-ling
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.06.2012; Public Library of Science (PLoS)
• Subjects: Aberration; Activin; Activin Receptors, Type II - genetics; Activin Receptors, Type II - metabolism; Adult; Angiogenesis; Assaying; Biology; Blood pressure; Breast cancer; Cell cycle; Cell Line; Comparative analysis; Cyclin D1 - genetics; Cyclin D1 - metabolism; Cyclin D3 - genetics; Cyclin D3 - metabolism; Epigenetics; Evolutionary biology; Female; Gene Expression; Gene Expression Regulation; Genes; Gestation; Gynecology; Humans; Hypertension; Laboratories; Medicine; MicroRNAs; MicroRNAs - genetics; Obstetrics; Pathogenesis; Placenta; Placenta - metabolism; Placenta - pathology; Pre-eclampsia; Pre-Eclampsia - genetics; Preeclampsia; Pregnancy; Pregnant women; Proteinuria; Ribonucleic acid; RNA; Signal transduction; Signaling; Tissues; Trophoblasts - metabolism; Trophoblasts - pathology; Western blotting; Young Adult; Zoology; Beijing China; China

Preeclampsia (PE) is a pregnancy-specific syndrome manifested by on-set of hypertension and proteinuria after 20 weeks of gestation. Abnormal placenta development has been generally accepted as initial cause of the disorder. Recently, miR-195 was found to be down-regulated in preeclamptic placentas...