Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens

• Published in: PloS one Vol. 15; no. 6; p. e0235248
• Main Authors: Bravi, Francesca, Flacco, Maria Elena, Carradori, Tiziano, Volta, Carlo Alberto, Cosenza, Giuseppe, De Togni, Aldo, Acuti Martellucci, Cecilia, Parruti, Giustino, Mantovani, Lorenzo, Manzoli, Lamberto
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.06.2020; Public Library of Science (PLoS)
• Subjects: Age; Angiotensin; Angiotensin converting enzyme inhibitors; Angiotensin II; Angiotensin II receptor blockers; Angiotensin Receptor Antagonists - adverse effects; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive Agents - therapeutic use; Betacoronavirus - physiology; Biology and life sciences; Cardiovascular disease; Cardiovascular diseases; Case-Control Studies; Chronic obstructive pulmonary disease; Converting; Coronavirus Infections - complications; Coronavirus Infections - drug therapy; Coronavirus Infections - epidemiology; Coronaviruses; COVID-19; Diabetes; Diabetes mellitus; Disease transmission; Drug therapy; Electronic health records; Electronic medical records; Enzyme inhibitors; Enzymes; Female; Guidelines as Topic; Health services; Hospitals; Humans; Hypertension; Hypertension - drug therapy; Infections; Inhibitors; Intensive care; Italy - epidemiology; Kidney diseases; Laboratories; Male; Males; Medicine and health sciences; Middle Aged; Mortality; Multivariate analysis; Pandemics; Patients; Peptidyl-dipeptidase A; Physicians; Pneumonia, Viral - complications; Pneumonia, Viral - drug therapy; Pneumonia, Viral - epidemiology; Pre-existing conditions; Prognosis; Public health; Receptors; Retrospective Studies; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Signs and symptoms; Statistics; Viral diseases; Italy

This retrospective case-control study was aimed at identifying potential independent predictors of severe/lethal COVID-19, including the treatment with Angiotensin-Converting Enzyme inhibitors (ACEi) and/or Angiotensin II Receptor Blockers (ARBs). All adults with SARS-CoV-2 infection in two Italian...