Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?

• Published in: PloS one Vol. 10; no. 7; p. e0133392
• Main Authors: Spampinato, Simona F., Obermeier, Birgit, Cotleur, Anne, Love, Anna, Takeshita, Yukio, Sano, Yasuteru, Kanda, Takashi, Ransohoff, Richard M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.07.2015; Public Library of Science (PLoS)
• Subjects: Adult; Astrocytes; Astrocytes - cytology; Astrocytes - metabolism; Blood; Blood & organ donations; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain; Brain research; Cell adhesion & migration; Cell culture; Cell death; Cell Movement; Cell Survival; Central nervous system; Cerebrospinal fluid; Colony-stimulating factor; Cytokines; Cytokines - metabolism; Egress; Endothelial cells; Endothelial Cells - cytology; Endothelium; Fingolimod Hydrochloride - chemistry; Granulocyte-macrophage colony-stimulating factor; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Healthy Volunteers; Humans; Immunology; Inflammation; Leukocyte migration; Leukocytes; Leukocytes - cytology; Lipids; Lymph nodes; Lymphatic system; Lysophospholipids - metabolism; Macrophages; Mechanical stimuli; Metabolism; Microcirculation; Middle Aged; Modulation; Multiple sclerosis; Multiple Sclerosis - immunology; Neurology; Neurosciences; Pathogenesis; Phosphates; Receptor mechanisms; Receptors; Receptors, Lysosphingolipid - metabolism; Review boards; Shear stress; Signal Transduction; Signaling; Sphingolipids - chemistry; Sphingosine; Sphingosine - analogs & derivatives; Sphingosine - metabolism; Stress, Mechanical; Studies; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0133392

The ability of the Blood Brain Barrier (BBB) to maintain proper barrier functions, keeping an optimal environment for central nervous system (CNS) activity and regulating leukocytes' access, can be affected in CNS diseases. Endothelial cells and astrocytes are the principal BBB cellular constit...