Molecular characterization of circulating tumor cells in human metastatic colorectal cancer

• Published in: PloS one Vol. 7; no. 7; p. e40476
• Main Authors: Barbazán, Jorge, Alonso-Alconada, Lorena, Muinelo-Romay, Laura, Vieito, María, Abalo, Alicia, Alonso-Nocelo, Marta, Candamio, Sonia, Gallardo, Elena, Fernández, Beatriz, Abdulkader, Ihab, de Los Ángeles Casares, María, Gómez-Tato, Antonio, López-López, Rafael, Abal, Miguel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.07.2012; Public Library of Science (PLoS)
• Subjects: Analysis; Bioinformatics; Biology; Biomarkers; Biomarkers, Tumor - analysis; Cancer; Cancer metastasis; Cell adhesion & migration; Cell death; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - pathology; Detachment; Diagnostic systems; DNA microarrays; Gene expression; Genes; Genetic aspects; Humans; Hybridization; Laboratories; Leukemia; Liver; Liver Neoplasms - secondary; Lung carcinoma; Lung Neoplasms - secondary; Mechanical properties; Medical prognosis; Medicine; Metastases; Metastasis; Neoplastic Cells, Circulating - metabolism; Oligonucleotide Array Sequence Analysis; Oncology; Patients; Prognosis; Signaling; Stem cells; Transcriptome; Tumor cells; Spain

Metastatic colorectal cancer (mCRC) relies on the detachment of aggressive malignant cells from the primary tumor into the bloodstream and, concordantly, the presence of these Circulating Tumor Cells (CTC) is associated with a poor prognosis. In this work, the molecular characterization of CTC from...