Pharmacologic treatment of attention deficit hyperactivity disorder in adults: A systematic review and network meta-analysis

• Published in: PloS one Vol. 15; no. 10; p. e0240584
• Main Authors: Elliott, Jesse, Johnston, Amy, Husereau, Don, Kelly, Shannon E, Eagles, Caroline, Charach, Alice, Hsieh, Shu-Ching, Bai, Zemin, Hossain, Alomgir, Skidmore, Becky, Tsakonas, Eva, Chojecki, Dagmara, Mamdani, Muhammad, Wells, George A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.10.2020; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Amphetamine - adverse effects; Amphetamine - therapeutic use; Amphetamines; Atomoxetine Hydrochloride - adverse effects; Atomoxetine Hydrochloride - therapeutic use; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - epidemiology; Attention Deficit Disorder with Hyperactivity - pathology; Attention deficit hyperactivity disorder; Bayes Theorem; Bayesian analysis; Bias; Biology and Life Sciences; Bupropion; Bupropion - adverse effects; Bupropion - therapeutic use; Central Nervous System Stimulants - adverse effects; Clinical decision making; Clinical trials; Computer and Information Sciences; Decision making; Dextroamphetamine - adverse effects; Dextroamphetamine - therapeutic use; Drug therapy; Drug-Related Side Effects and Adverse Reactions - classification; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; Emergency medical care; Emergency medical services; Executive function; Female; Guanfacine - adverse effects; Guanfacine - therapeutic use; Health risks; Humans; Intervention; Lisdexamfetamine Dimesylate - adverse effects; Lisdexamfetamine Dimesylate - therapeutic use; Long-term effects; Male; Medicine and Health Sciences; Meta-analysis; Methylphenidate; Methylphenidate - adverse effects; Methylphenidate - therapeutic use; Modafinil; Modafinil - adverse effects; Modafinil - therapeutic use; Network Meta-Analysis; Patient outcomes; Patients; Pharmacology; Physical Sciences; Quality of Life; Randomized Controlled Trials as Topic; Research and Analysis Methods; Risk analysis; Risk assessment; Salts; Canada; Toronto Ontario Canada; Ottawa Ontario Canada

Attention deficit hyperactivity disorder (ADHD) affects approximately 3% of adults globally. Many pharmacologic treatments options exist, yet the comparative benefits and harms of individual treatments are largely unknown. We performed a systematic review and network meta-analysis to assess the rela...