Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions

• Published in: PloS one Vol. 8; no. 9; p. e74011
• Main Authors: Yin, Songyue, Xue, Jin, Sun, Haidan, Wen, Bo, Wang, Quanhui, Perkins, Guy, Zhao, Huiwen W, Ellisman, Mark H, Hsiao, Yu-hsin, Yin, Liang, Xie, Yingying, Hou, Guixue, Zi, Jin, Lin, Liang, Haddad, Gabriel G, Zhou, Dan, Liu, Siqi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.09.2013; Public Library of Science (PLoS)
• Subjects: Abundance; Adaptation; Adaptation, Physiological; Animals; Apoptosis; Calcium; Confidence intervals; Correlation analysis; Drosophila; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; E coli; Electron microscopy; Electron Transport; Escherichia coli; Gene regulation; Genomes; Genomics; Hyperoxia; Hyperoxia - genetics; Hyperoxia - metabolism; Hypoxia; Hypoxia - genetics; Hypoxia - metabolism; Insects; Kinases; Laboratories; Medicine; Microscopy; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Mitochondria - ultrastructure; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Organelles; Oxidation-Reduction; Oxidative Stress; Oxygen; Oxygen tension; Pediatrics; Phenotype; Physiology; Post-transcription; Proteins; Proteome; Proteomics - methods; Quantitation; Quantitative analysis; Rodents; Tissues; Transcriptome; Transmission electron microscopy; Beijing China; California; United States > US; China

Mitochondria are the primary organelles that consume oxygen and provide energy for cellular activities. To investigate the mitochondrial mechanisms underlying adaptation to extreme oxygen conditions, we generated Drosophila strains that could survive in low- or high-oxygen environments (LOF or HOF,...