Circulating miRNAs as Potential Marker for Pulmonary Hypertension
MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNA...
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| Published in | PloS one Vol. 8; no. 5; p. e64396 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
23.05.2013
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0064396 |
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| Abstract | MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNAs of mild-to-severe human PH subjects and, compared them with the control subjects by miRNA array. Blood was obtained using fluoroscopic and waveform guided catheterization from the distal (pulmonary artery) port of the catheter. A total 40 human subjects were included in the study and, the degree of PH was determined by mean pulmonary arterial pressure. Among several miRNAs in the array, we validated 14 miRNAs and, the data were consistent with the array profile. We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects. Our study showed novel set of miRNAs which are dysregulated in PH and, are directly proportional to the degree of PH. These miRNAs may be considered as potential biomarker for early detection of PH. |
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| AbstractList | MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNAs of mild-to-severe human PH subjects and, compared them with the control subjects by miRNA array. Blood was obtained using fluoroscopic and waveform guided catheterization from the distal (pulmonary artery) port of the catheter. A total 40 human subjects were included in the study and, the degree of PH was determined by mean pulmonary arterial pressure. Among several miRNAs in the array, we validated 14 miRNAs and, the data were consistent with the array profile. We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects. Our study showed novel set of miRNAs which are dysregulated in PH and, are directly proportional to the degree of PH. These miRNAs may be considered as potential biomarker for early detection of PH. MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNAs of mild-to-severe human PH subjects and, compared them with the control subjects by miRNA array. Blood was obtained using fluoroscopic and waveform guided catheterization from the distal (pulmonary artery) port of the catheter. A total 40 human subjects were included in the study and, the degree of PH was determined by mean pulmonary arterial pressure. Among several miRNAs in the array, we validated 14 miRNAs and, the data were consistent with the array profile. We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects. Our study showed novel set of miRNAs which are dysregulated in PH and, are directly proportional to the degree of PH. These miRNAs may be considered as potential biomarker for early detection of PH.MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection of miRNAs in circulation of pulmonary hypertensive (PH) human subjects remains elusive. In the current study, we determined the pattern of miRNAs of mild-to-severe human PH subjects and, compared them with the control subjects by miRNA array. Blood was obtained using fluoroscopic and waveform guided catheterization from the distal (pulmonary artery) port of the catheter. A total 40 human subjects were included in the study and, the degree of PH was determined by mean pulmonary arterial pressure. Among several miRNAs in the array, we validated 14 miRNAs and, the data were consistent with the array profile. We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects. Our study showed novel set of miRNAs which are dysregulated in PH and, are directly proportional to the degree of PH. These miRNAs may be considered as potential biomarker for early detection of PH. |
| Audience | Academic |
| Author | Arroliga, Alejandro C. Henderson, Heather Li, Li Wei, Chuanyu Kim, Il-Kwon Spradley, Christopher Kumar, Sandeep Hong, Nayeon Gupta, Sudhiranjan |
| AuthorAffiliation | Wageningen UR Livestock Research, The Netherlands 1 Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M Health Science Center, Scott & White, Central Texas Veterans Health Care System, Temple, Texas, United States of America 2 Scott & White Memorial Hospital, Temple, Texas, United States of America |
| AuthorAffiliation_xml | – name: 1 Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M Health Science Center, Scott & White, Central Texas Veterans Health Care System, Temple, Texas, United States of America – name: 2 Scott & White Memorial Hospital, Temple, Texas, United States of America – name: Wageningen UR Livestock Research, The Netherlands |
| Author_xml | – sequence: 1 givenname: Chuanyu surname: Wei fullname: Wei, Chuanyu – sequence: 2 givenname: Heather surname: Henderson fullname: Henderson, Heather – sequence: 3 givenname: Christopher surname: Spradley fullname: Spradley, Christopher – sequence: 4 givenname: Li surname: Li fullname: Li, Li – sequence: 5 givenname: Il-Kwon surname: Kim fullname: Kim, Il-Kwon – sequence: 6 givenname: Sandeep surname: Kumar fullname: Kumar, Sandeep – sequence: 7 givenname: Nayeon surname: Hong fullname: Hong, Nayeon – sequence: 8 givenname: Alejandro C. surname: Arroliga fullname: Arroliga, Alejandro C. – sequence: 9 givenname: Sudhiranjan surname: Gupta fullname: Gupta, Sudhiranjan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23717609$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.yjmcc.2011.07.011 10.1038/ncb1596 10.1038/nm.2021 10.1097/MOL.0b013e328350a425 10.1016/S0092-8674(03)00759-1 10.1093/eurheartj/ehq013 10.1038/nature07242 10.1084/jem.20101812 10.1016/j.tcb.2011.12.001 10.1161/CIRCGENETICS.110.958975 10.1161/CIRCRESAHA.109.215566 10.1164/rccm.201106-1130OC 10.1038/mt.2010.254 10.1126/science.1174381 10.4103/2045-8932.83444 10.1038/nature07228 10.1161/ATVBAHA.111.226696 10.1161/CIRCGENETICS.110.957415 10.1371/journal.pone.0003694 10.1371/journal.pone.0005532 10.1152/ajpheart.00756.2011 10.1159/000328869 10.7326/0003-4819-115-5-343 10.1126/scisignal.2000610 10.1016/S0092-8674(04)00045-5 10.1073/pnas.0804549105 10.1161/CIRCRESAHA.111.247742 10.1016/j.cardfail.2010.01.002 10.1161/CIRCRESAHA.107.163147 10.1093/eurheartj/ehp297 10.1513/pats.201002-024AW 10.1038/ncb2210 10.1016/j.rmed.2010.12.018 10.1152/ajplung.00316.2011 10.1097/MCC.0b013e3283382e58 10.1373/clinchem.2009.125310 10.1152/physiolgenomics.00141.2011 10.1016/j.vph.2011.08.001 10.1161/CIRCULATIONAHA.111.060269 |
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| Copyright | COPYRIGHT 2013 Public Library of Science 2013 Wei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Wei et al 2013 Wei et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: SG. Performed the experiments: CW HH LL IK SK NH. Analyzed the data: CW HH CS LL IK SK AC SG. Contributed reagents/materials/analysis tools: HH CS AC. Wrote the paper: HH CS SG. Competing Interests: The authors have declared that no competing interests exist. |
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| References | Z Safdar (ref8) 2011; 105 ATF Members (ref25) 2009; 30 KM Drake (ref36) 2011; 184 GK Wang (ref15) 2010; 31 H Valadi (ref41) 2007; 9 Y Akao (ref18) 2011; 19 S Yang (ref38) 2012; 302 M Tanaka (ref14) 2009; 4 A Chida (ref33) 2012 T Boettger (ref10) 2012; 110 MV Latronico (ref11) 2007; 101 JA Stamm (ref9) 2011; 1 GE D'Alonzo (ref7) 1991; 115 O Gidlof (ref17) 2011; 118 M Satoh (ref31) 2010; 16 KC Vickers (ref28) 2012; 23 VV McLaughlin (ref5) 2009; 53 S Kumar (ref35) 2012; 302 S Fichtlscherer (ref23) 2011; 31 MF Corsten (ref29) 2010; 3 VN Parikh (ref37) 2012; 125 PS Mitchell (ref22) 2008; 105 S Fichtlscherer (ref24) 2010; 107 X Li (ref26) 2009; 15 DP Bartel (ref1) 2004; 116 X Ji (ref13) 2009; 55 C Widera (ref32) 2011; 51 MA Simon (ref6) 2010; 16 A Zernecke (ref21) 2009; 2 W Li (ref34) 2010; 7 A Courboulin (ref39) 2011; 208 AJ Kriegel (ref27) 2012; 44 D Baek (ref3) 2008; 455 Y Kuwabara (ref30) 2011; 4 V Di Stefano (ref12) 2011; 55 X Chen (ref19) 2012; 22 KC Vickers (ref40) 2011; 13 MP Hunter (ref20) 2008; 3 A Bonauer (ref16) 2009; 324 DS Schwarz (ref2) 2003; 115 M Selbach (ref4) 2008; 455 19855400 - Nat Med. 2009 Nov;15(11):1289-97 17486113 - Nat Cell Biol. 2007 Jun;9(6):654-9 22374147 - Circ J. 2012;76(6):1501-8 19460962 - Science. 2009 Jun 26;324(5935):1710-3 20159880 - Eur Heart J. 2010 Mar;31(6):659-66 19389575 - J Am Coll Cardiol. 2009 Apr 28;53(17):1573-619 21102562 - Mol Ther. 2011 Feb;19(2):395-9 18063818 - Circ Res. 2007 Dec 7;101(12):1225-36 19996457 - Sci Signal. 2009 Dec 8;2(100):ra81 21701171 - Cardiology. 2011;118(4):217-26 21273054 - Respir Med. 2011 Jun;105(6):818-27 19002258 - PLoS One. 2008;3(11):e3694 21321078 - J Exp Med. 2011 Mar 14;208(3):535-48 20595655 - Circ Res. 2010 Sep 3;107(5):677-84 22011751 - Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2383-90 18663219 - Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8 20921333 - Circ Cardiovasc Genet. 2010 Dec;3(6):499-506 22461364 - Circ Res. 2012 Mar 30;110(7):1000-13 22371328 - Circulation. 2012 Mar 27;125(12):1520-32 22227207 - Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L521-9 20179591 - Curr Opin Crit Care. 2010 Jun;16(3):237-43 22260888 - Trends Cell Biol. 2012 Mar;22(3):125-32 21423178 - Nat Cell Biol. 2011 Apr;13(4):423-33 22034603 - Pulm Circ. 2011 Apr-Jun;1(2):138-59 21806992 - J Mol Cell Cardiol. 2011 Nov;51(5):872-5 22245771 - Am J Physiol Heart Circ Physiol. 2012 Apr 15;302(8):H1655-66 19440243 - PLoS One. 2009;4(5):e5532 21920918 - Am J Respir Crit Care Med. 2011 Dec 15;184(12):1400-8 14567917 - Cell. 2003 Oct 17;115(2):199-208 20447577 - J Card Fail. 2010 May;16(5):404-10 22214600 - Physiol Genomics. 2012 Feb 27;44(4):237-44 1863023 - Ann Intern Med. 1991 Sep 1;115(5):343-9 21642241 - Circ Cardiovasc Genet. 2011 Aug 1;4(4):446-54 18668037 - Nature. 2008 Sep 4;455(7209):64-71 14744438 - Cell. 2004 Jan 23;116(2):281-97 19713419 - Eur Heart J. 2009 Oct;30(20):2493-537 19696117 - Clin Chem. 2009 Nov;55(11):1944-9 21030519 - Proc Am Thorac Soc. 2010 Nov;7(6):395-8 22418571 - Curr Opin Lipidol. 2012 Apr;23(2):91-7 18668040 - Nature. 2008 Sep 4;455(7209):58-63 21846509 - Vascul Pharmacol. 2011 Oct;55(4):111-8 |
| References_xml | – volume: 51 start-page: 872 year: 2011 ident: ref32 article-title: Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2011.07.011 – volume: 9 start-page: 654 year: 2007 ident: ref41 article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells publication-title: Nat Cell Biol doi: 10.1038/ncb1596 – year: 2012 ident: ref33 article-title: Missense Mutations of the BMPR1B (ALK6) Gene in Childhood Idiopathic Pulmonary Arterial Hypertension publication-title: Circ J – volume: 15 start-page: 1289 year: 2009 ident: ref26 article-title: Notch3 signaling promotes the development of pulmonary arterial hypertension publication-title: Nat Med doi: 10.1038/nm.2021 – volume: 23 start-page: 91 year: 2012 ident: ref28 article-title: Lipid-based carriers of microRNAs and intercellular communication publication-title: Curr Opin Lipidol doi: 10.1097/MOL.0b013e328350a425 – volume: 115 start-page: 199 year: 2003 ident: ref2 article-title: Asymmetry in the assembly of the RNAi enzyme complex publication-title: Cell doi: 10.1016/S0092-8674(03)00759-1 – volume: 31 start-page: 659 year: 2010 ident: ref15 article-title: Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans publication-title: Eur Heart J doi: 10.1093/eurheartj/ehq013 – volume: 455 start-page: 64 year: 2008 ident: ref3 article-title: The impact of microRNAs on protein output publication-title: Nature doi: 10.1038/nature07242 – volume: 208 start-page: 535 year: 2011 ident: ref39 article-title: Role for miR-204 in human pulmonary arterial hypertension publication-title: J Exp Med doi: 10.1084/jem.20101812 – volume: 22 start-page: 125 year: 2012 ident: ref19 article-title: Secreted microRNAs: a new form of intercellular communication publication-title: Trends in Cell Biology doi: 10.1016/j.tcb.2011.12.001 – volume: 4 start-page: 446 year: 2011 ident: ref30 article-title: Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage publication-title: Circ Cardiovasc Genet doi: 10.1161/CIRCGENETICS.110.958975 – volume: 107 start-page: 677 year: 2010 ident: ref24 article-title: Circulating microRNAs in patients with coronary artery disease publication-title: Circ Res doi: 10.1161/CIRCRESAHA.109.215566 – volume: 184 start-page: 1400 year: 2011 ident: ref36 article-title: Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201106-1130OC – volume: 19 start-page: 395 year: 2011 ident: ref18 article-title: Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages publication-title: Mol Ther doi: 10.1038/mt.2010.254 – volume: 53 start-page: 1573 year: 2009 ident: ref5 article-title: ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association publication-title: J Am Coll Cardiol – volume: 324 start-page: 1710 year: 2009 ident: ref16 article-title: MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice publication-title: Science doi: 10.1126/science.1174381 – volume: 1 start-page: 138 year: 2011 ident: ref9 article-title: Overview of current therapeutic approaches for pulmonary hypertension publication-title: Pulm Circ doi: 10.4103/2045-8932.83444 – volume: 455 start-page: 58 year: 2008 ident: ref4 article-title: Widespread changes in protein synthesis induced by microRNAs publication-title: Nature doi: 10.1038/nature07228 – volume: 31 start-page: 2383 year: 2011 ident: ref23 article-title: Circulating microRNAs: biomarkers or mediators of cardiovascular diseases? publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.111.226696 – volume: 3 start-page: 499 year: 2010 ident: ref29 article-title: Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease publication-title: Circ Cardiovasc Genet doi: 10.1161/CIRCGENETICS.110.957415 – volume: 3 start-page: e3694 year: 2008 ident: ref20 article-title: Detection of microRNA Expression in Human Peripheral Blood Microvesicles publication-title: PLoS One doi: 10.1371/journal.pone.0003694 – volume: 4 start-page: e5532 year: 2009 ident: ref14 article-title: Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients publication-title: PLoS One doi: 10.1371/journal.pone.0005532 – volume: 302 start-page: H1655 year: 2012 ident: ref35 article-title: Cardiac-specific genetic inhibition of nuclear factor-kappaB prevents right ventricular hypertrophy induced by monocrotaline publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00756.2011 – volume: 118 start-page: 217 year: 2011 ident: ref17 article-title: Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples publication-title: Cardiology doi: 10.1159/000328869 – volume: 115 start-page: 343 year: 1991 ident: ref7 article-title: Survival in patients with primary pulmonary hypertension. Results from a national prospective registry publication-title: Ann Intern Med doi: 10.7326/0003-4819-115-5-343 – volume: 2 start-page: ra81 year: 2009 ident: ref21 article-title: Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection publication-title: Sci Signal doi: 10.1126/scisignal.2000610 – volume: 116 start-page: 281 year: 2004 ident: ref1 article-title: MicroRNAs: genomics, biogenesis, mechanism, and function publication-title: Cell doi: 10.1016/S0092-8674(04)00045-5 – volume: 105 start-page: 10513 year: 2008 ident: ref22 article-title: Circulating microRNAs as stable blood-based markers for cancer detection publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.0804549105 – volume: 110 start-page: 1000 year: 2012 ident: ref10 article-title: A new level of complexity: the role of microRNAs in cardiovascular development publication-title: Circ Res doi: 10.1161/CIRCRESAHA.111.247742 – volume: 16 start-page: 404 year: 2010 ident: ref31 article-title: Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy publication-title: J Card Fail doi: 10.1016/j.cardfail.2010.01.002 – volume: 101 start-page: 1225 year: 2007 ident: ref11 article-title: Emerging role of microRNAs in cardiovascular biology publication-title: Circ Res doi: 10.1161/CIRCRESAHA.107.163147 – volume: 30 start-page: 2493 year: 2009 ident: ref25 article-title: Guidelines for the diagnosis and treatment of pulmonary hypertension publication-title: Eur Heart J doi: 10.1093/eurheartj/ehp297 – volume: 7 start-page: 395 year: 2010 ident: ref34 article-title: Bone morphogenetic protein type II receptor mutations causing protein misfolding in heritable pulmonary arterial hypertension publication-title: Proc Am Thorac Soc doi: 10.1513/pats.201002-024AW – volume: 13 start-page: 423 year: 2011 ident: ref40 article-title: MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins publication-title: Nat Cell Biol doi: 10.1038/ncb2210 – volume: 105 start-page: 818 year: 2011 ident: ref8 article-title: Treatment of pulmonary arterial hypertension: the role of prostacyclin and prostaglandin analogs publication-title: Respir Med doi: 10.1016/j.rmed.2010.12.018 – volume: 302 start-page: L521 year: 2012 ident: ref38 article-title: miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00316.2011 – volume: 16 start-page: 237 year: 2010 ident: ref6 article-title: Right ventricular adaptation to pressure overload publication-title: Curr Opin Crit Care doi: 10.1097/MCC.0b013e3283382e58 – volume: 55 start-page: 1944 year: 2009 ident: ref13 article-title: Plasma miR-208 as a biomarker of myocardial injury publication-title: Clin Chem doi: 10.1373/clinchem.2009.125310 – volume: 44 start-page: 237 year: 2012 ident: ref27 article-title: The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury publication-title: Physiological Genomics doi: 10.1152/physiolgenomics.00141.2011 – volume: 55 start-page: 111 year: 2011 ident: ref12 article-title: microRNAs as peripheral blood biomarkers of cardiovascular disease publication-title: Vascular Pharmacology doi: 10.1016/j.vph.2011.08.001 – volume: 125 start-page: 1520 year: 2012 ident: ref37 article-title: MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.111.060269 – reference: 20179591 - Curr Opin Crit Care. 2010 Jun;16(3):237-43 – reference: 21423178 - Nat Cell Biol. 2011 Apr;13(4):423-33 – reference: 22214600 - Physiol Genomics. 2012 Feb 27;44(4):237-44 – reference: 22011751 - Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2383-90 – reference: 22374147 - Circ J. 2012;76(6):1501-8 – reference: 22461364 - Circ Res. 2012 Mar 30;110(7):1000-13 – reference: 22034603 - Pulm Circ. 2011 Apr-Jun;1(2):138-59 – reference: 22245771 - Am J Physiol Heart Circ Physiol. 2012 Apr 15;302(8):H1655-66 – reference: 20921333 - Circ Cardiovasc Genet. 2010 Dec;3(6):499-506 – reference: 18063818 - Circ Res. 2007 Dec 7;101(12):1225-36 – reference: 21846509 - Vascul Pharmacol. 2011 Oct;55(4):111-8 – reference: 22260888 - Trends Cell Biol. 2012 Mar;22(3):125-32 – reference: 21701171 - Cardiology. 2011;118(4):217-26 – reference: 14744438 - Cell. 2004 Jan 23;116(2):281-97 – reference: 21806992 - J Mol Cell Cardiol. 2011 Nov;51(5):872-5 – reference: 14567917 - Cell. 2003 Oct 17;115(2):199-208 – reference: 18663219 - Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8 – reference: 17486113 - Nat Cell Biol. 2007 Jun;9(6):654-9 – reference: 22371328 - Circulation. 2012 Mar 27;125(12):1520-32 – reference: 19996457 - Sci Signal. 2009 Dec 8;2(100):ra81 – reference: 21642241 - Circ Cardiovasc Genet. 2011 Aug 1;4(4):446-54 – reference: 21321078 - J Exp Med. 2011 Mar 14;208(3):535-48 – reference: 19460962 - Science. 2009 Jun 26;324(5935):1710-3 – reference: 22227207 - Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L521-9 – reference: 19713419 - Eur Heart J. 2009 Oct;30(20):2493-537 – reference: 18668037 - Nature. 2008 Sep 4;455(7209):64-71 – reference: 22418571 - Curr Opin Lipidol. 2012 Apr;23(2):91-7 – reference: 20447577 - J Card Fail. 2010 May;16(5):404-10 – reference: 21102562 - Mol Ther. 2011 Feb;19(2):395-9 – reference: 19002258 - PLoS One. 2008;3(11):e3694 – reference: 21030519 - Proc Am Thorac Soc. 2010 Nov;7(6):395-8 – reference: 21273054 - Respir Med. 2011 Jun;105(6):818-27 – reference: 19696117 - Clin Chem. 2009 Nov;55(11):1944-9 – reference: 19440243 - PLoS One. 2009;4(5):e5532 – reference: 21920918 - Am J Respir Crit Care Med. 2011 Dec 15;184(12):1400-8 – reference: 20595655 - Circ Res. 2010 Sep 3;107(5):677-84 – reference: 19855400 - Nat Med. 2009 Nov;15(11):1289-97 – reference: 20159880 - Eur Heart J. 2010 Mar;31(6):659-66 – reference: 18668040 - Nature. 2008 Sep 4;455(7209):58-63 – reference: 19389575 - J Am Coll Cardiol. 2009 Apr 28;53(17):1573-619 – reference: 1863023 - Ann Intern Med. 1991 Sep 1;115(5):343-9 |
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| SubjectTerms | Biology Biomarkers Biomarkers - blood Blood Buffy Coat - metabolism Blood pressure Cardiology Cardiovascular disease Case-Control Studies Catheterization Comparative analysis Down-Regulation Ethics Female Fluoroscopy Gene Expression Genomics Heart Heart diseases Heart failure Hospitals Humans Hypertension Hypertension, Pulmonary - blood Intubation Male Medical instruments Medicine MicroRNA MicroRNAs MicroRNAs - blood MicroRNAs - genetics miRNA Mortality Mutation Pathogenesis Patients Pulmonary arteries Pulmonary artery Pulmonary hypertension Ribonucleic acid RNA Rodents Science Sex Characteristics |
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| Title | Circulating miRNAs as Potential Marker for Pulmonary Hypertension |
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