Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension

• Published in: PloS one Vol. 7; no. 10; p. e45469
• Main Authors: Mi, Xue-Song, Feng, Qian, Lo, Amy Cheuk Yin, Chang, Raymond Chuen-Chung, Lin, Bin, Chung, Sookja Kim, So, Kwok-Fai
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.10.2012; Public Library of Science (PLoS)
• Subjects: Aging; Alzheimer's disease; Alzheimers disease; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Animal cognition; Animals; Biology; Blood; Blood vessels; Blood-Retinal Barrier - drug effects; Blood-Retinal Barrier - metabolism; Blood-Retinal Barrier - pathology; Brain research; Care and treatment; Chinese medicine; Damage prevention; Degeneration; Diabetes; Disease Models, Animal; Down-Regulation - drug effects; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Endothelin 1; Endothelin-1 - genetics; Endothelin-1 - metabolism; Eye; Eye injuries; Eye manifestations; Gene Expression - drug effects; Glaucoma; Goji berries; Health aspects; Hypertension; Immunoglobulin G; Immunoglobulin G - metabolism; Injury prevention; Ischemia; Laboratory animals; Leakage; Lycium barbarum; Male; Medicine; Mice; Mice, Inbred C57BL; Nerve Degeneration - genetics; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Nerve Degeneration - prevention & control; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Neurosciences; Ocular Hypertension - genetics; Ocular Hypertension - metabolism; Ocular Hypertension - pathology; Ocular Hypertension - prevention & control; Pathogenesis; Polysaccharides; Proteins; Receptor for Advanced Glycation End Products; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; Retina; Retinal ganglion cells; Retinal Ganglion Cells - drug effects; Retinal Ganglion Cells - metabolism; Retinal Ganglion Cells - pathology; Retinal Vessels - drug effects; Retinal Vessels - metabolism; Retinal Vessels - pathology; Retinopathy; Rodents; Saccharides; Science; Signal Transduction - drug effects; Signaling; Studies; Systematic review; Therapeutic applications; Thinning; Tight junctions; Tight Junctions - drug effects; Tight Junctions - metabolism; Tight Junctions - pathology; Traditional Chinese medicine; Hong Kong China; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0045469

Acute ocular hypertension (AOH) is a condition found in acute glaucoma. The purpose of this study is to investigate the protective effect of Lycium barbarum polysaccharides (LBP) and its protective mechanisms in the AOH insult. LBP has been shown to exhibit neuroprotective effect in the chronic ocul...