Stress-Induced Changes of Hippocampal NMDA Receptors: Modulation by Duloxetine Treatment

• Published in: PloS one Vol. 7; no. 5; p. e37916
• Main Authors: Calabrese, Francesca, Guidotti, Gianluigi, Molteni, Raffaella, Racagni, Giorgio, Mancini, Michele, Riva, Marco Andrea
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.05.2012; Public Library of Science (PLoS)
• Subjects: Abnormalities; Animals; Antidepressants; Antidepressive Agents - pharmacology; Anxiety - complications; Behavior; Behavior, Animal - drug effects; Biology; Brain; Depression (Mood disorder); Duloxetine; Duloxetine Hydrochloride; Emotional disorders; Etiology; Exposure; Gene Expression Regulation - drug effects; Genetic engineering; Glutamate; Glutamatergic transmission; Glutamic acid receptors (ionotropic); Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - physiopathology; Ketamine; Laboratory animals; Male; Medicine; Memory - drug effects; Mental depression; Metabolism; Modulation; N-Methyl-D-aspartic acid receptors; Pathology; Phosphorylation; Phosphorylation - drug effects; Physiology; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiopathology; Protein Subunits - genetics; Protein Subunits - metabolism; Public health; Rats; Rats, Sprague-Dawley; Receptors; Receptors, N-Methyl-D-Aspartate - genetics; Receptors, N-Methyl-D-Aspartate - metabolism; Rodents; Spatial Behavior - drug effects; Spatial Behavior - physiology; Stress; Stress (Psychology); Stress, Psychological - complications; Stress, Psychological - genetics; Stress, Psychological - metabolism; Stress, Psychological - physiopathology; Stresses; Studies; Synapses; Thiophenes - pharmacology; Transcription; Italy

It is now well established that the glutamatergic system contributes to the pathophysiology of depression. Exposure to stress, a major precipitating factor for depression, enhances glutamate release that can contribute to structural abnormalities observed in the brain of depressed subjects. On the o...