Structural Brain Changes after Traditional and Robot-Assisted Multi-Domain Cognitive Training in Community-Dwelling Healthy Elderly

The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Parti...

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Published inPloS one Vol. 10; no. 4; p. e0123251
Main Authors Kim, Geon Ha, Jeon, Seun, Im, Kiho, Kwon, Hunki, Lee, Byung Hwa, Kim, Ga Young, Jeong, Hana, Han, Noh Eul, Seo, Sang Won, Cho, Hanna, Noh, Young, Park, Sang Eon, Kim, Hojeong, Hwang, Jung Won, Yoon, Cindy W., Kim, Hee Jin, Ye, Byoung Seok, Chin, Ju Hee, Kim, Jung-Hyun, Suh, Mee Kyung, Lee, Jong Min, Kim, Sung Tae, Choi, Mun-Taek, Kim, Mun Sang, Heilman, Kenneth M, Jeong, Jee Hyang
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 21.04.2015
Public Library of Science (PLoS)
Subjects
Age
Aged
Brain
Brain - pathology
Cognition
Cognitive ability
Cognitive Therapy - methods
Cortex
Dementia - prevention & control
Elderly
Female
Geriatrics
Humans
Independent Living
Male
Middle Aged
Older people
Organ Size
Robotics
Robots
Thinning
Training
Treatment Outcome
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Abstract The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly. ClnicalTrials.gov NCT01596205.
AbstractList The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly. Trial Registration ClnicalTrials.gov NCT01596205
The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly. Trial Registration ClnicalTrials.gov NCT01596205
The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly.
The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly. ClnicalTrials.gov NCT01596205.
The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly.ClnicalTrials.gov NCT01596205.
The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly.UNLABELLEDThe purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly.ClnicalTrials.gov NCT01596205.TRIAL REGISTRATIONClnicalTrials.gov NCT01596205.
Audience Academic
Author Hwang, Jung Won
Im, Kiho
Kim, Jung-Hyun
Kim, Ga Young
Kim, Hee Jin
Kim, Sung Tae
Cho, Hanna
Kim, Mun Sang
Heilman, Kenneth M
Choi, Mun-Taek
Chin, Ju Hee
Ye, Byoung Seok
Park, Sang Eon
Kwon, Hunki
Yoon, Cindy W.
Lee, Jong Min
Kim, Geon Ha
Jeon, Seun
Lee, Byung Hwa
Jeong, Hana
Noh, Young
Han, Noh Eul
Kim, Hojeong
Jeong, Jee Hyang
Seo, Sang Won
Suh, Mee Kyung
AuthorAffiliation 13 Center for Intelligent Robotics at Korea Institute Science and Technology, Seoul, Korea
9 Department of Neurology, Inha University Hospital, Inha University School of Medicine, Incheon, Korea
5 Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
MRC Institute of Hearing Research, UNITED KINGDOM
6 Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
10 Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
4 Division of Newborn Medicine, Boston Children′s Hospital, Harvard Medical School, Boston, Massachustetts, United States of America
1 Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea
8 Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Korea
14 Department of Neurology, University of Florida College of Medicine, and the Veterans Affairs Medical Center, Gainesvill
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/25898367$$D View this record in MEDLINE/PubMed
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This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”) Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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– notice: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”) Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Competing Interests: Dr. S.W. Seo received research support from the Ministry for Health, Welfare and Family Affairs, Korea. Dr. D.L. Na received research support from Gaha Corporation through a research grant to Samsung Medical Center, and a grant from the Ministry for Health, Welfare and Family Affairs, Korea. All other authors report no disclosures. We do not have any other relevant relationships including employment, consultancy, products in development, marketed products or patent rights from Gaha Corporation. Although Samsung Medical Center has made a contract with Gaha Corporation to receive a royalty from Robocare for the software programs fitted in the robot, none of the authors including Dr. Na benefit from this personally. The authors declare that neither funding from Gaha Corporation nor the reception of royalty from Robocare alters the authors' adherence to PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: GHK DLN MSK MTC. Performed the experiments: GHK GYK HJ NEH JHC JHK MKS SEP Hojeong K. HC YN Hee Jin K. CWY BSY STK MSK MTC SWS. Analyzed the data: SJ KI HKK BHL SWS JML. Contributed reagents/materials/analysis tools: STK MSK MTC SEP Hojeong K. JWH DLN JHJ JML. Wrote the paper: GHK KMH DLN.
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Snippet The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of...
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SourceType Open Website
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StartPage e0123251
SubjectTerms Age
Aged
Brain
Brain - pathology
Cognition
Cognitive ability
Cognitive Therapy - methods
Cortex
Dementia - prevention & control
Elderly
Female
Geriatrics
Humans
Independent Living
Male
Middle Aged
Older people
Organ Size
Robotics
Robots
Thinning
Training
Treatment Outcome
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Title Structural Brain Changes after Traditional and Robot-Assisted Multi-Domain Cognitive Training in Community-Dwelling Healthy Elderly
URI https://www.ncbi.nlm.nih.gov/pubmed/25898367
https://www.proquest.com/docview/1674683741
https://www.proquest.com/docview/1675869764
https://pubmed.ncbi.nlm.nih.gov/PMC4405358
https://doaj.org/article/1caccf2f098943808995372b1eb1c910
http://dx.doi.org/10.1371/journal.pone.0123251
Volume 10
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