Human Herpesvirus 8 (HHV8) Sequentially Shapes the NK Cell Repertoire during the Course of Asymptomatic Infection and Kaposi Sarcoma

• Published in: PLoS pathogens Vol. 8; no. 1; p. e1002486
• Main Authors: Dupuy, Stéphanie, Lambert, Marion, Zucman, David, Choukem, Siméon-Pierre, Tognarelli, Sara, Pages, Cécile, Lebbé, Céleste, Caillat-Zucman, Sophie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2012; Public Library of Science (PLoS)
• Subjects: Asymptomatic Infections; Base Sequence; Biology; Cells; Cells, Cultured; Development and progression; Health aspects; Herpesviridae Infections - complications; Herpesviridae Infections - immunology; Herpesviridae Infections - virology; Herpesvirus; Herpesvirus 8, Human - immunology; Herpesvirus 8, Human - physiology; HIV Infections - complications; HIV Infections - immunology; HIV-1 - immunology; HIV-1 - physiology; Human herpesvirus 8; Humans; Immune system; Immunology; Infections; Kaposi's sarcoma; Killer cells; Killer Cells, Natural - classification; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Lymphocyte Activation - physiology; Medicine; Middle Aged; Molecular Sequence Data; NK Cell Lectin-Like Receptor Subfamily K - metabolism; Phenotype; Physiological aspects; Proteins; Sarcoma; Sarcoma, Kaposi - complications; Sarcoma, Kaposi - immunology; Sarcoma, Kaposi - virology; Virus Latency - genetics; Virus Latency - immunology; France

The contribution of innate immunity to immunosurveillance of the oncogenic Human Herpes Virus 8 (HHV8) has not been studied in depth. We investigated NK cell phenotype and function in 70 HHV8-infected subjects, either asymptomatic carriers or having developed Kaposi's sarcoma (KS). Our results...