Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids

• Published in: PloS one Vol. 13; no. 8; p. e0202083
• Main Authors: Watanabe, Keita, Igarashi, Miki, Li, Xuan, Nakatani, Akiho, Miyamoto, Junki, Inaba, Yuka, Sutou, Asuka, Saito, Tsutomu, Sato, Takumi, Tachibana, Nobuhiko, Inoue, Hiroshi, Kimura, Ikuo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.08.2018; Public Library of Science (PLoS)
• Subjects: Adipose tissue; Animals; Bile; Bile acids; Bile Acids and Salts - metabolism; Bioaccumulation; Biodiversity; Biology and Life Sciences; Biotransformation; Body fat; Body weight; Body weight gain; Cecum; Diabetes; Diet; Diet, High-Fat - adverse effects; Dietary Supplements; Digestive system; Digestive tract; Excretion; Fatty liver; Gastrointestinal Microbiome - drug effects; Gene expression; Genetic transformation; Germfree; Glucagon; Glucagon-like peptide 1; Glucagon-Like Peptide 1 - metabolism; Health aspects; High fat diet; High protein diet; Hyperglycemia; Insulin; Intestinal microflora; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestine; Lipogenesis; Male; Medical research; Medicine and Health Sciences; Metabolic Networks and Pathways - drug effects; Metabolism; Metagenome; Metagenomics - methods; Mice; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Nutrition research; Obesity; Obesity - etiology; Obesity - metabolism; Phenotypes; Physiological aspects; Proteins; R&D; Research & development; Research and Analysis Methods; Risk factors; Rodents; Secretion; Soy protein; Soybean Proteins - pharmacology; Soybeans; Transformation; Weight reduction; Japan

The consumption of soybean protein has well-known favorable metabolic effects (e.g., reduced body weight, body fat, hyperglycemia, insulin resistance, hepatic steatosis, and lipogenesis). These effects of soy protein have been linked to modulation by the gut microbiota; however, the dynamic interpla...