Phenotyping of Human Melanoma Cells Reveals a Unique Composition of Receptor Targets and a Subpopulation Co-Expressing ErbB4, EPO-R and NGF-R

• Published in: PloS one Vol. 9; no. 1; p. e84417
• Main Authors: Mirkina, Irina, Hadzijusufovic, Emir, Krepler, Clemens, Mikula, Mario, Mechtcheriakova, Diana, Strommer, Sabine, Stella, Alexander, Jensen-Jarolim, Erika, Höller, Christoph, Wacheck, Volker, Pehamberger, Hubert, Valent, Peter
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.01.2014; Public Library of Science (PLoS)
• Subjects: Animals; Antigen (tumor-associated); Antigens; Antigens, CD - genetics; Antigens, CD - metabolism; B cells; Biology; Biotechnology; Boltzmann, Ludwig Eduard (1844-1906); Cancer metastasis; Cancer therapies; CD20 antigen; CD44 antigen; CD45 antigen; CD63 antigen; Cell Line, Tumor; Cell surface; Comparative analysis; Cytokine receptors; Cytokines; Cytometry; Dermatology; Disease; Drugs; ErbB-2 protein; ErbB-3 protein; Erythropoietin; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genetic transformation; Growth factors; Hematology; Humans; Immunophenotyping; Insulin-like growth factor I; Intercellular adhesion molecule 1; Interleukin 2 receptors; Kinases; Lesions; Male; MDR1 protein; Medical prognosis; Medicine; Melanocytes; Melanoma; Melanoma - genetics; Melanoma - metabolism; Melanoma - pathology; Metastases; Metastasis; Mice; Mice, Inbred NOD; Neoplasm Transplantation; Nerve growth factor; Oncology; Patients; PD-1 protein; Phenotyping; Prognosis; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - metabolism; Proto-Oncogene Proteins c-kit - deficiency; Proto-Oncogene Proteins c-kit - genetics; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Receptor, ErbB-4; Receptor, Nerve Growth Factor - genetics; Receptor, Nerve Growth Factor - metabolism; Receptors; Receptors, Erythropoietin - genetics; Receptors, Erythropoietin - metabolism; Skin; Skin cancer; Skin diseases; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Stem cells; Studies; Subpopulations; Transformation; Veterinary medicine; Austria

Malignant melanoma is a life-threatening skin cancer increasingly diagnosed in the western world. In advanced disease the prognosis is grave. Growth and metastasis formation in melanomas are regulated by a network of cytokines, cytokine-receptors, and adhesion molecules. However, little is known abo...