Inhibition of Enveloped Viruses Infectivity by Curcumin

• Published in: PloS one Vol. 8; no. 5; p. e62482
• Main Authors: Chen, Tzu-Yen, Chen, Da-Yuan, Wen, Hsiao-Wei, Ou, Jun-Lin, Chiou, Shyan-Song, Chen, Jo-Mei, Wong, Min-Liang, Hsu, Wei-Li
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2013; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Antioxidants; Antiviral agents; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Apoptosis; Biochemistry; Biology; Care and treatment; Cercopithecus aethiops; Chick Embryo; Curcumin; Curcumin - chemistry; Curcumin - pharmacology; Cytotoxicity; Dengue Virus - drug effects; Dogs; Encephalitis Virus, Japanese - drug effects; Enterovirus A, Human - drug effects; Fluorescence; Fluorescent indicators; Gene expression; Health aspects; Hemagglutination; Hepatitis; Infections; Infectivity; Influenza; Influenza A Virus, H1N1 Subtype - drug effects; Kinases; Leakage; Liposomes; Liposomes - chemistry; Madin Darby Canine Kidney Cells; Medicine; Membrane structure; Membranes; Newcastle disease virus - drug effects; Penicillin; Pharmacology; Proteins; Public health; R&D; Research & development; RNA polymerase; Sulforhodamine; Transfection; Turmeric; Vero Cells; Veterinary medicine; Viral Plaque Assay; Virology; Virus Internalization - drug effects; Viruses; United States

Curcumin, a natural compound and ingredient in curry, has antiinflammatory, antioxidant, and anticarcinogenic properties. Previously, we reported that curcumin abrogated influenza virus infectivity by inhibiting hemagglutination (HA) activity. This study demonstrates a novel mechanism by which curcu...