The G allele of the IGF1 rs2162679 SNP is a potential protective factor for any myopia: Updated systematic review and meta-analysis

• Published in: PloS one Vol. 17; no. 7; p. e0271809
• Main Authors: Meng, Bo, Wang, Kang, Huang, Yingxiang, Wang, Yanling
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.07.2022; Public Library of Science (PLoS)
• Subjects: Alleles; Analysis; Biology and Life Sciences; Care and treatment; Case-Control Studies; Confidence intervals; Genes; Genetic aspects; Genetic Predisposition to Disease; Genotype & phenotype; Growth factors; Humans; Igf1 gene; Insulin; Insulin-like growth factor I; Insulin-Like Growth Factor I - genetics; Kinases; Medicine and Health Sciences; Meta-analysis; Myopia; Myopia - genetics; Nucleotides; Outdoor activities; People and Places; Physical Sciences; Polymorphism, Single Nucleotide; Protective Factors; Research and Analysis Methods; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Systematic review; China

The insulin-like growth factor 1 (IGF1) gene is located within the myopia-associated MYP3 interval, which suggests it may play an important role in the progression of myopia. However, the association between IGF1 SNPs and any myopia is rarely reported. A comprehensive literature search was conducted...