p53 Acts as a Co-Repressor to Regulate Keratin 14 Expression during Epidermal Cell Differentiation

• Published in: PloS one Vol. 7; no. 7; p. e41742
• Main Authors: Cai, Bi-He, Hsu, Pei-Ching, Hsin, I-Lun, Chao, Chung-Faye, Lu, Mei-Hua, Lin, Hwang-Chi, Chiou, Shih-Hwa, Tao, Pao-Luh, Chen, Jang-Yi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.07.2012; Public Library of Science (PLoS)
• Subjects: 12-O-Tetradecanoylphorbol-13-acetate; Acetic acid; Affinity; Apoptosis; Base Pairing - genetics; Base Sequence; Benzothiazoles - pharmacology; Binding sites; Biology; Cell differentiation; Cell Differentiation - drug effects; Cell Differentiation - genetics; Cells, Cultured; Co-Repressor Proteins - metabolism; Deoxyribonucleic acid; Differentiation (biology); DNA; Epidermis - cytology; Foreskin - cytology; Gene expression; Gene Expression Regulation - drug effects; Genes, Dominant - genetics; Hospitals; Humans; Inhibition; Keratin; Keratin-14 - genetics; Keratin-14 - metabolism; Keratinocytes; Keratinocytes - cytology; Keratinocytes - drug effects; Keratinocytes - metabolism; Kinases; Male; Medical research; Models, Biological; Molecular Sequence Data; Mutant Proteins - metabolism; Mutation; Nucleotides; Overexpression; p53 Protein; Phosphorylation; Phosphorylation - drug effects; Precipitation (Meteorology); Promoter Regions, Genetic - genetics; Protein Binding - drug effects; Proteins; Psoriasis; Repressing; Rodents; Sp1 protein; Sp1 Transcription Factor - metabolism; Teratocarcinoma; Tetradecanoylphorbol Acetate - pharmacology; Toluene - analogs & derivatives; Toluene - pharmacology; Transcription; Tumor proteins; Tumor Suppressor Protein p53 - antagonists & inhibitors; Tumor Suppressor Protein p53 - metabolism; Up-Regulation - drug effects; Up-Regulation - genetics; China; Taiwan

During epidermal cell differentiation, keratin 14 (K14) expression is down-regulated, p53 expression varies, and the expression of the p53 target genes, p21 and 14-3-3σ, increases. These trends suggest that the relative transcriptional activity of p53 is increased during epidermal cell differentiati...