Virtual Electrophysiological Study of Atrial Fibrillation in Fibrotic Remodeling

• Published in: PloS one Vol. 10; no. 2; p. e0117110
• Main Authors: McDowell, Kathleen S., Zahid, Sohail, Vadakkumpadan, Fijoy, Blauer, Joshua, MacLeod, Rob S., Trayanova, Natalia A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2015; Public Library of Science (PLoS)
• Subjects: Ablation; Ablation (Surgery); Aged; Analysis; Arrhythmia; Atria; Atrial fibrillation; Atrial Fibrillation - pathology; Atrial Fibrillation - physiopathology; Atrial Fibrillation - therapy; Biomedical engineering; Cardiac arrhythmia; Cardiovascular Diseases - pathology; Cardiovascular Diseases - physiopathology; Catheter Ablation; Catheters; Critical components; Electrophysiologic Techniques, Cardiac - methods; Electrophysiological recording; Electrophysiology; Engineering; Female; Fibrillation; Fibrosis; Fibrosis - pathology; Fibrosis - physiopathology; Heart Atria - pathology; Heart Atria - physiopathology; Humans; Lesions; Magnetic Resonance Imaging; Mathematical models; Middle Aged; Modelling; NMR; Nuclear magnetic resonance; Patients; Rotors; Sensitivity analysis; Singularities; Success; Target recognition; United States > US; Maryland; Utah; Baltimore Maryland

Research has indicated that atrial fibrillation (AF) ablation failure is related to the presence of atrial fibrosis. However it remains unclear whether this information can be successfully used in predicting the optimal ablation targets for AF termination. We aimed to provide a proof-of-concept that...